Transcription repressor

Details Transcription repressor Transcription repressor

1997-05-22

1999-02-23

Saunders, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 435325, 514 44, 536 235, C12P 2100, C12N 1512, C12N 510, C07H 2104

Patent

active

058742468

ABSTRACT:
The present invention provides a human transcription repressor (TRAREP) and polynucleotides which identify and encode TRAREP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing TRAREP and for treating or preventing disorders associated with expression of TRAREP.

REFERENCES:
Vogel, F. and Motulsky, A.G. in "Human Genetics: Problems and Approaches," Vogel and Motulsky, eds. Springer-Verlag, Berlin. pp. 18-29, 1982.
Goppelt, A., et al., "A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains", The EMBO Journal 15(12): 3105-3116 (1996).
Mermelstein, F., et al., "Requirement of a corepressor for Drl-mediated repression of transcription", Gene & Development, 10:1033-1048 (1996).
Goppelt, A.R., et al., (GI 1491709) GenBank Sequence Database (Accession X96506), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (1491710).
Mermelstein, F., et al., (GI 1244713) GenBank Sequence Database (Accession U41843), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (1244714).

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