Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2003-04-02
2009-12-01
McGarry, Sean R (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S022100, C536S024100, C514S04400A
Reexamination Certificate
active
07626007
ABSTRACT:
Disclosed herein is an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1. The isolated polypeptide binds to the DNA binding domain located from −550 to −487 in the promoter of the human TNF-α gene. Additionally, the level of the mRNA transcript encoding the isolated polypeptide is substantially increased in response to LPS stimulation in cultured THP-1 cells.
REFERENCES:
patent: 6077693 (2000-06-01), Tang et al.
Kalota, et al. (2006) Progress in the Development of Nucleic Acid Therapeutics. Hep, v.173: 173-196.
Takashiba et al., Infect. lmmun. 63: 1529-1534 (1995).
Neuenschwander et al., Endocrinology 136: 4298-4303 (1995).
Stein, C.A., Antisense and Nucleic Acid Drug Dev. 8: 129-132 (1998).
Helene et al., Ciba Foundation Symposium 209: 94-102 (1997).
Agrawal and Iyer, Pharm. Ther. 76: 151-160 (1997).
Yao et al., J. of Biol. Chem. 272(28): 17795-801 (1997).
Beutler er al., Science 229: 869-871 (1985).
Tracey et al., Science 234: 470-474 (1986).
Miethke et al., J. Exp. Med. 175:91-98 (1992).
Tracey et al., J. Exp. Med. 167: 1211-1227 (1988).
Rink and Kirchner, Int. Arch. Allergy lmmunol. 111: 199-209 (1996).
Polyak et al., Nature Sep. 18; 389 (6648): 300-305 (1997).
Amar and Myokai, GenBank deposit U77396 (1996).
Amar and Myokai, GenBank deposit NM 004862 (1996).
Clark & Elbing LLP
McGarry Sean R
Pitrak Jennifer
Trustees of Boston University
LandOfFree
Transcription factor regulating TNF-α does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transcription factor regulating TNF-α, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transcription factor regulating TNF-α will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4145602