Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2007-07-10
2007-07-10
Qian, Celine (Department: 1636)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S350000, C435S070100, C435S007100
Reexamination Certificate
active
10130872
ABSTRACT:
The polypeptide of the present invention has an activity of binding specifically to the cis-element of Chondromodulin-I (ChM-I) gene promoter and promoting the transcription of the ChM-I gene. The polypeptide of the present invention is usable in screening for a compound that promotes or inhibits the activity of the polypeptide.
REFERENCES:
patent: 5851775 (1998-12-01), Barker et al.
patent: 0 473 080 (1992-03-01), None
patent: 07-138295 (1995-05-01), None
Y. Hiraki, et al.; “Identification of Chondromodulin I as a Novel Endothelial Cell Growth Inhibitor”; J. of Biological Chemistry; vol. 272; No. 51; pp. 32419-32426; 1997.
Y. Hiraki, et al.; “Molecular Cloning of a New Class of Cartilage-Specific Matrix, Chondromodulin-I, Which Stimulates Growth of Cultured Chondrocytes”; Biochemical and Biophysical Research Communications; vol. 175; No. 3; pp. 971-977; 1991.
Yanagihara, et al., “Genomic Organization of the Human Chondromodulin-I Gene Containing a Promoter Region That Confers the Expression of Reporter Gene in Chondrogenic ATDC5 Cells,” Journal of Bone and Mineral Research, vol. 15, No. 3, Mar. 2000, pp. 421-429.
Shukunami, et al., “Generation of Multiple Transcripts from the Chicken Chondromodulin-I Gene and Their Expression During Embryonic Development,” FEBS Letters. Netherlands Jul. 30, 1999, vol. 456, No. 1, pp. 165-170.
Hikichi Yuichi
Noguchi Ken-ichi
Yoshimura Koji
Conlin David G.
Dunston Jennifer
Edwards Angell Palmer & & Dodge LLP
O'Day Christine C.
Qian Celine
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