Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Metal containing – e.g. – chromoproteins – ferritin,...
Reexamination Certificate
2009-01-30
2011-11-15
Dunston, Jennifer (Department: 1636)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Metal containing, e.g., chromoproteins, ferritin,...
C530S350000
Reexamination Certificate
active
08058408
ABSTRACT:
Using an undifferentiated mouse CL6 cell line, DMSO was added to induce its differentiation into cardiac muscular cells in order to obtain gene fragments whose expression elevated upon the induction. The isolated gene had zinc finger domains and showed a significant homology to the Sp1 family genes. Furthermore, a human gene corresponding to this mouse gene was isolated. The protein encoded by this gene existed in the nucleus and bonded to a GC-box. The protein was revealed to repress the transcription regulatory activity of the CMV promoter and thus serves as a transcription factor.
REFERENCES:
patent: 5288607 (1994-02-01), Emorine et al.
patent: 5807678 (1998-09-01), Miller et al.
patent: 5831008 (1998-11-01), Huang et al.
patent: 6008048 (1999-12-01), Monia
patent: WO-98/02455 (1998-01-01), None
De Luca et al. Sp3 represses transcription when tethered to promoter DNA or targeted to promoter proximal RNA. The Journal of Biological Chemistry, vol. 271, No. 15, pp. 8533-8536, Apr. 1996.
GenBank Database Accession No. CAA48562.1, GI: 38418, Mar. 1993.
Brunskill et al. Characterization of Npas3, a novel basic helix-loop-helix PAS gene expressed in the developing mouse nervous system. Mechanisms of Development, vol. 88, pp. 237-241, Nov. 1999.
Cook et al., Annals of the New York Academy of Sciences (1999) 880(1):94-102.
Courey et al., Cell (1988) 55:887-898.
Database EMBL, Accession No. AI275629 [1998].
Database EMBL, Accession No. AL033342 [1999].
Dynan et al., Cell (1983) 35:79-87.
GenBank Database, Accession No. AC007405.1, GI 4680771, Apr. 1999.
GenBank Database, Accession No. AC007405.3, GI 7631078 [Apr. 21, 2000].
GenBank Database, Accession No. AF279479, GI 9454415 [2001].
GenBank Database, Accession No. AW303983, GI 6713672 [Jan. 18, 2000].
Gidoni et al., Nature (1984) 312:409-413.
Habara-Ohkubo, Cell Struct Funct (1996) 21(2):101-110.
Hagan et al., EMBO J (1994) 13:3843-3851.
Hagan et al., Nucleic Acids Res (1992) 20:5519-5525.
Harrison et al., Developmental Biology (2000) 227:358-372.
Imataka et al., EMBO J (1992) 11(10):3663-3671.
Kadonaga et al., Cell (1987) 51:1079-1090.
Kingsley et al., Mol Cell Biol (1992) 12:4251-4261.
Philipsen et al., Nucleic Acids Res (1999) 27:2991-3000.
Luu and Flores, Journal of Virology (1997) 71(9):6683-6691.
Scohy et al., Genomics (2000) 70:93-101.
Supplementary Partial European Search Report for EP 01938663.0, mailed on Jan. 16, 2006, 5 pages.
Treichel et al., Mechanisms of Development (2001) 101:175-179.
Whisstock et al., Q Rev Biophys (2003) 36(3):307-340.
Williams et al., Molecular and Cellular Biology (1989) 9(6):2574-2587.
Zhu et al., Mol Cell Biol (1993) 13(7):4432-4444.
Numata Mariko
Senoo Chiaki
Chugai Seiyaku Kabushiki Kaisha
Dunston Jennifer
Morrison & Foerster / LLP
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