Transcription factor for regulation of the development of skin a

Details Transcription factor for regulation of the development of skin a Transcription factor for regulation of the development of skin a

1993-03-22

1996-01-16

Stone, Jacqueline M.

Chemistry: molecular biology and microbiology

Vector, per se

530350, 536 235, 930 10, 935 9, 935 18, 935 19, 935 21, 935 23, C12N 1511, C12N 1512, C12N 1563, C07K 1400

Patent

active

054847320

ABSTRACT:
A gene encoding for alternative forms of a POU domain transcription factor is disclosed. The first polypeptide form of the transcription factor includes a transferable region which inhibits DNA binding by itself and other transcription factors. The second polypeptide form serves to activate expression of a gene typical for terminal differentiation of skin. Fusion proteins wherein the inhibitory region of the first form of the gene is coupled to, and inhibits the function of, other transcription factors are also disclosed.

REFERENCES:
A. Goldsborough et al (1990) 18 (6): 1634.
A. Goldsborough et al (1993) 21 (1): 127-134.

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