Transcription factor E2F DNA-binding domain inhibitor...

Details Transcription factor E2F DNA-binding domain inhibitor... Transcription factor E2F DNA-binding domain inhibitor...

2005-01-11

2005-01-11

McKelvey, Terry (Department: 1636)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C530S324000, C530S325000, C530S326000, C530S327000, C530S328000, C530S329000, C530S350000, C424S185100

Reexamination Certificate

active

06841385

ABSTRACT:
The present invention provides peptides which bind to the DNA binding domain of transcription factor E2F, and inhibit cell cycle progression. Peptides include FWLRFT (SEQ ID NO:1); WVRWHF (SEQ ID NO:2); WHFIFW (SEQ ID NO:3); IWLSGLSRGVWVSFP (SEQ ID NO:4); and GSRILTFRSGSWYAS (SEQ ID NO:5) and derivatives based upon these sequences. Compositions and the use of the peptides in inhibiting cell cycle progression, such as in uncontrolled cell proliferation, are also provided.

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L R Bandhara et al.: “Apaptosis induced in mammalian cells by small peptides that functionally antagonize the Rb-regulated E2F transcription factor” Nature Biotechnology., vol. 15, No. 9, Sep. 1997, pp. 896-901, XP002061240 Nature Publishing., US.
File Medline, abstract 95059071 XP002137731 & M Xu et al.: “Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E″F-1/DP-1 by phosphorylation” Molecular and Cellular Biology., vol. 14, No. 12, Dec. 1994, pp. 8420-8431, American Society for Microbiology, Washington., US.
File Medline, abstract 92236563, 1992 XP002137732 & S M Stirdivant et al.: “Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product” Molecular and Cellular Biology., vol. 12, No. 5, May 1992, pp. 1905-1914, American Society for Microbiology, Washington., US.

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