Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1996-09-30
1999-01-12
McKelvey, Terry
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530300, 530324, C07K 1447
Patent
active
058591990
ABSTRACT:
The invention provides polypeptides of transcription factor DP-3 which exists in four isoforms produced by alternative splicing of mRNA, nucleic acid encoding the polypeptides and the use of such nucleic acid and polypeptides in assays. Two isoforms of DP-3 contain a region, designated the E region, which is a nuclear localization signal and is involved in a further level of regulation of DP-3 and its ability to bind to E2F-1 and regulate the cell cycle.
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de la Luna Susana
La Thangue Nicholas B.
McKelvey Terry
Prolifix Limited
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