Transcription factor DP-1

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S006120, C435S007100, C436S501000, C436S518000

Reexamination Certificate

active

09645572

ABSTRACT:
The invention provides a polynucleotide in substantially isolated form which includes a contiguous sequence of nucleotides which is capable of selectively hybridizing to SEQ ID NO: 1 or the complement of SEQ ID NO: 1, and a polypeptide in substantially isolated form which includes: (a) the protein in SEQ ID NO: 2; or (b) an allelic variant or species homologue thereof; or (c) a protein at least 70% homologous to (a); or (d) a fragment of any one of (a) to (c) capable of forming a complex with the E2 F-1 protein or related family member; or (e) a fragment of any one of (a) to (c) of at least 15 amino acids.

REFERENCES:
patent: WO 93/15227 (1993-08-01), None
Cao et al, Nature (ENGLAND) Jan. 9, 1992, 355 (6356) p. 176-9, ISSN 0028-0836.
Bowie et al (Science, 1990, 247:1306-1310).
Burgess et al (J of Cell Bio. 111:2129-2138, 1990).
Lazar et al (Molecular and Cellular Biology, 1988, 8:1247-1252).
Darbinian et al., J Cell Physiol. 2001 Dec.;189(3):334-40.
Gura (Science, 1997, 278:1041-1042).
Jain (Sci. Am., 1994, 271:58-65).
Curti (Crit. Rev. in Oncology/Hematology, 1993, 14:29-39).
Hartwell et al (Science, 1997, 278:1064-1068).
Benzene structure downloaded from en.wikipedia.org on Jan. 5, 2006).
Naphalene downloaded from en.wikipedia.org on Jan. 5, 2006.
Shivji et al., Mol. Cell. Biol. vol. 11 (3) 1991, 1686-1695.
Watson et al., Molecular Biology (1987), Fourth Edition, vol. 1, p. 313.
Crystal, R.G., Science 270: 404-410, 1995.
Miller et al., FASEB J. 9. 190-199, 1995.
Madeline et al., PNAS 83:6761-6765.
Bekkers et al., Biochemica et Biophysica Acta 1089: 345-351, 1991.
Zamanian et al., The EMBO Journal vol. 11 No. 7 pp. 2603-2610, 1992, “Adevnovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor”.
Kaelin et al., Cell, vol. 70, 351-364, Jul. 24, 1992, “Expression Cloning of a cDNA Encoding a Retinoblastoma-Binding Protein withE1F-like Properties”.
Girling et al., Nature vol. 362, pp. 83-87 Mar. 4, 1993, “A new component of the transcription factor DRTF1/E2F”.
LaThangue et al., Current Biology 1993, vol. 3 No. 8, pp. 554-557,“Transcriptional Complexity”.
Helin et al., Genes & Development 7i:1850-1861 1993, “Heterodimerization of the Transcription Factors E2F-1 and DP-1 Leads to Cooperative Trans-Activation”.
Galfe, G. and Milstein, C. Preparation of Monoclonal Antibodies: Strategies and Procedures, Methods in Enzymology 73: 3-46 (1981).
Goding, James. Monoclonal Antibodies: Principles and Practice, 118-123 (1983).
AS, Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex, EMBO J., Jul. 1987;6(7):2061-8, Abstract.
AS, The adenovirus-inducible factor stimulates transcription after specfic DNA binding, Mol Cell Biol., Feb. 1989;9(2):578-85, Abstract.
Thalmeier, Nuclear factor E2F mediates basic transcription and transactivation b E1a of the human MYC promoter, Genes Dev., Apr. 1989;3(4):527-36, Abstract.
Hiebert, E1A-dependent trans-activation of the human MYC promoter is media by the E2F factor, Proc. Natl Acad Sci, May 1989;86(10):3594-8, Abstract.
Babiss, The cellular transcription factor E2f requires viral E1A and E4 gene products for incrased DNA-binding activity and functions to stimulat adenovirus E2A gene expression, J Virol., Jun. 1989;63(6):2709-17, Abstract.
Bagchi, Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system, Proc Natl Acad Sci, Jun. 1989;86(12):4352-6, Abstract.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Transcription factor DP-1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transcription factor DP-1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transcription factor DP-1 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3778562

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.