Transcription factor complexes in senescent cells

Details Transcription factor complexes in senescent cells Transcription factor complexes in senescent cells

1995-08-29

1998-01-06

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 6, 435 74, 435 15, 435194, 436 63, 436 86, 530350, 530358, C07K 14435, C12Q 168, G01N 3350, G01N 33573

Patent

active

057053502

ABSTRACT:
A method of screening a cell for the onset of senescence or a senescent state therein comprises detecting a p21-E2F complex in the cell, an elevation in the complex as compared to a normal cell indicating the onset of senescence or a senescent state in the cell. Isolated complexes comprised of p21 and E2F are also disclosed. The complexes stably bind to DNA and are useful, among other things, for binding DNA.

REFERENCES:
patent: 5302706 (1994-04-01), Smith
patent: 5384255 (1995-01-01), Ciechanover et al.
patent: 5473056 (1995-12-01), Ivey-Hoyle et al.
patent: 5491069 (1996-02-01), Dirmi et al.
N. Dyson; pRB, p107 and the regulation of the E2F transcription factor, J. Cell Science, Supplement 18:81-87 (1994).
Y. Ziong et al.; p21 is a universal inhibitor of cyclin kinases, Letters to Nature 366:701-704 (1993).

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