Transacylases of the paclitaxel biosynthetic pathway

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Reexamination Certificate

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C435S045000, C435S069100, C435S252300, C435S252800, C435S320100, C435S325000, C536S023200

Reexamination Certificate

active

07153676

ABSTRACT:
Transacylase enzymes and the use of such enzymes to produce paclitaxel, related taxoids, as well as intermediates in the paclitaxel biosynthetic pathway are disclosed. Also disclosed are nucleic acid sequences encoding the transacylase enzymes.

REFERENCES:
patent: 6818755 (2004-11-01), Croteau et al.
patent: 2002/0138859 (2002-09-01), Croteau et al.
patent: 2003/0108891 (2003-06-01), Croteau et al.
patent: WO 99/40216 (1999-08-01), None
patent: WO 01/23586 (2001-04-01), None
GenBank Accession No. X66785, version X66785.1 (GI:30489), submitted to GenBank Jun. 7, 1992, last revised Aug. 11, 2005 at 9:43 AM.
GenBank Accession No. CAA47285, version CAA47285.1 (GI:30490), submitted to GenBank Jun. 7, 1992, last revised Aug. 11, 2005 at 9:43 AM.
GenBank Accession No. X66785, version X66785.1 (GI:30489), submitted to GenBank Jun. 7, 1992, last revised Jun. 7, 2000.
GenBank Accession No. CAA47285, version CAA47285.1 (GI:30490), submitted to GenBank Jun. 7, 1992, last revised Jun. 5, 2000.
U.S. Appl. No. 10/421,633, filed Apr. 21, 2003, Croteau et al.
Walker and Croteau, “Taxol biosythesis: Molecular cloning of a benzoyl-CoA:taxane 2α- O-benzoyltransferase cDNA from Taxus and functional expression inEscherichia coli,”PNAS, 97:13591-13596, 2000.
Wildung and Croteau, “A cDNA Clone for Taxadiene Synthase, the Diterpene Cyclase That Catalyzes the Committed Step of Taxol Biosynthesis,”J. Biol. Chem., 271(16):9201-9204, 1996.
Zocher et al., “Biosynthesis of Taxol: Enzymatic Acetylation of 10-Deacetylbaccatin-III to Baccatin-III in Crude Extracts from Roots of Taxus baccata,”Biochem. Biophys. Res. Comm., 16-20, 1996.
GenBank Accession No. CAA47285 (1992).
GenBank Accession No. X66785 (1992).
Hezari and Croteau, “Taxol Biosynthesis: An Update,”Planta Medica, 63:291-295, 1997.
Menhard and Zenk, “Purification and characterization of acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase from cell suspension cultures ofTaxus chinensi ,” Phytochemistry, 50:763-774, 1999.
Pennington et al., “Acetyl CoA:10-deacetylbaccatin-III-10-O-acetyl transferase activity in leaves and cell suspension cultures ofTaxus cuspidate,” Pharmaceuticals, 49(8):2261-2266, 1998.
Walker and Croteau, “Molecular Cloning of 10-deacetylbaccatin-III-10-O-acetyl transferase cDNA fromTaxusand functional expression inEscherichia coli,” PNAS, 97(2):583-587, 2000.
Walker et al., “Molecular Cloning of a Taxa-4(20),11(12)-dien-5α-01-O-Acetyl Transferase cDNA fromTaxusand Functional Expression inEscherichia coli,” Arch. Biochem. Biophys., 374(2):371-380, 2000.
Walker et al., “Partial Purification and Characterization of Acetyl Conenzyme A: Taxa-4(20),11(12)-dien-5α-ol O-Acetyl Transferase That Catalyzes the First Acylation Step of Taxol Biosynthesis,”Arch. Biochem. Biophys., 364:273-279, 1999.

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