Trans-.DELTA..sup.2 -prostaglandin D derivatives, process for th

Details Trans-.DELTA..sup.2 -prostaglandin D derivatives, process for th Trans-.DELTA..sup.2 -prostaglandin D derivatives, process for th

1983-06-28

1985-12-31

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514570, 514573, 514908, 560 51, 560 53, 560118, 560121, 562459, 562463, 562500, 562503, 536103, C07C17700, A61K 31557

Patent

active

045622043

ABSTRACT:
Trans-.DELTA..sup.2 -prostaglandin D derivatives of the formula: ##STR1## wherein [A] is a group of the formula: ##STR2## X is ethylene or cis-vinylene, C.sub.13 -C.sub.14 -C.sub.15 is: (i) a group of the formula: ##STR3## when [A] is a group of the formula (II) or (III), or (ii) a group of the formula: ##STR4## when [A] is a group of the formula (IV), R is hydrogen or alkyl, R.sup.1 is a single bond or alkylene, R.sup.2 is alkyl, cycloalkyl, phenyl or phenoxy, the double bonds between C.sub.2 -C.sub.3 and between C.sub.13 -C.sub.14 are both E, the double bond between C.sub.9 -C.sub.10 is Z and the double bonds between C.sub.12 -C.sub.13 and between C.sub.14 -C.sub.15 are E, Z or a mixture thereof, provided that when R.sup.1 is a single bond, R.sup.2 does not represent a substituted or unsubstituted phenoxy group, and cyclodextrin clathrates and non-toxic salts thereof, possess anti-tumor activity.

REFERENCES:
patent: 3954844 (1976-05-01), Colton
patent: 4123463 (1978-10-01), Bundy
Corey, Experiment 19, 39 1084 (1983).

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