Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors

Details Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors

1984-12-10

1987-03-03

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514343, 548517, 548562, 548515, 548465, 548453, 546281, 546270, 546271, 546272, 544236, C07D40506, A61K 3140

Patent

active

046475761

ABSTRACT:
6-[2-(Substituted-pyrrol-1-yl)alkyl]pyran-2-ones and the corresponding ring-opened hydroxy-acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMG-CoA reductase), and are thus useful hypolipidemic and hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of treatment employing such pharmaceutical compositions are also disclosed.

REFERENCES:
patent: 3983140 (1976-09-01), Endo et al.
patent: 4198425 (1980-04-01), Mistui et al.
patent: 4219560 (1980-08-01), Houlihan
patent: 4248889 (1981-02-01), Oka et al.
patent: 4255444 (1981-03-01), Oka et al.
patent: 4308378 (1981-12-01), Stokker
patent: 4343811 (1982-08-01), Humaus et al.
patent: 4351844 (1982-09-01), Patchett et al.
patent: 4375425 (1983-03-01), Willard et al.
patent: 4376863 (1983-03-01), Lam
patent: 4440927 (1984-04-01), Prugh
Hulcher, Archives of Biochemistry and Biophysics, 146, (1971), pp. 422-427.

Affiliated with

Also associated with

Rating

Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1016911