Trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds and

Details Trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds and Trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds and

1989-11-22

1991-03-05

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142355, 514255, 514318, 514332, 514333, 514335, 514339, 514343, 514352, 544 60, 544124, 544360, 546143, 546256, 546261, 546264, 546272, 546275, 546309, 546297, C07D21364

Patent

active

049978349

ABSTRACT:
A trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different, and respectively represent hydrogen, C.sub.1-10 alkyl, C.sub.2-5 alkanoyl, formyl, C.sub.1-4 alkoxy-carbonyl, amidino, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylcarbonyl, phenyl, phenylalkyl, benzoyl, naphthoyl, phenylalkoxycarbonyl, benzylidene, pyridylcarbonyl, piperidyl, pyrrolidylidene or piperidylidene which may be optionally substituted on the ring or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form 5 to 6-membered cycle which may have oxygen atom, sulfur atom or optionally substituted nitrogen atom in the cycle, or together with the adjacent nitrogen atom form phthalimido, R.sup.3 represents hydrogen or C.sub.1-4 alkyl, R.sup.4 represents hydrogen or C.sub.1-4 alkyl, R.sup.5 represents hydrogen, hydroxy, C.sub.1-4 alkyl or phenylalkoxy. R.sup.6 represents hydrogen or C.sub.1-4 alkyl, A represents single bond, C.sub.1-5 straight chain alkylene, or alkylene which is substituted by C.sub.1-4 alkyl, n represents 0 to 1, an optical isomer thereof and a pharmaceutically acceptable acid addition salt thereof.
These compounds possess antihypertensive activity, and coronary, cerebral and kidney circulation-improving activities and are useful as antihypertensive agents and agents for prevention and treatment of circulatory diseases.

REFERENCES:
Chemical Abstracts, vol. 111, No. 19, Abstract 173,989t, p. 763, Nov. 6, 1989.

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