Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-01-30
2007-01-30
Turner, Sharon (Department: 1649)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C424S423000
Reexamination Certificate
active
10022301
ABSTRACT:
The invention relates to an antagonist of one or more of Rho family members having ability to elicit neurite outgrowth from cultured neurons in an assay method which includes culturing neurons on a substrate that incorporates a growth-inhibiting amount of Rho family member and exposing the cultured neurons to a candidate Rho family member antagonist agent to permit neuron growth. Candidates which elicit neurite outgrowth from the cultured neurons are thus identified as Rho family antagonists.
REFERENCES:
patent: 4997834 (1991-03-01), Muro et al.
patent: 5134121 (1992-07-01), Obley et al.
patent: 5543498 (1996-08-01), Fishman et al.
patent: 5645829 (1997-07-01), Shockley et al.
patent: 5661033 (1997-08-01), Ho et al.
patent: 5672344 (1997-09-01), Kelley et al.
patent: 5851786 (1998-12-01), Johnson et al.
patent: 6180597 (2001-01-01), Liao et al.
patent: 6218410 (2001-04-01), Uehata et al.
patent: 6451825 (2002-09-01), Uehata et al.
patent: 2263425 (1998-02-01), None
patent: 0 370 498 (1990-05-01), None
patent: WO 97/18303 (1997-05-01), None
patent: WO 98/46754 (1998-10-01), None
patent: WO 99/08533 (1999-02-01), None
Sylvani et al., Pediatric Neurology, 10(3):228-32, 1994.
Eberlein et al., Br. J. Pharmacol., 133:1172-1180, 2001.
Varon et al., J. of Neurotrauma 11(5):473-486, 1994.
Takahashi et al., Biochem. & Biophys. Res. Communications, 190(3):1156-62, 1993.
Caporale et al., PNAS 92:75-82, 1995.
Jalink et al. (1994) J. of Cell Biol. 126(3):801-810.
Li et al. PNAS (1980) 77(6):3211-3214.
McKerracher et al. (1999) Exp. Opin. Ther. Patents 9(11):1571-1574.
Jackowski, (1995) Br. J. of Neurosurgery 9:303-317.
Zalish et al. (1993) Retina 13:145-147.
Bartsch et al. (1995) Neuron 15:1375-1381.
Amano et al. (1997) Science 275:1308-1311.
Chardin et al. (1988) Nucleic Acids Research 16:2717.
Diekmann et al. (1995) Methods in Enzymology 256:207-215.
Dillon et al. (1995) Methods in Enzymology 256:174-195.
Hall (1994) Annu. Rev. Cell Biol. 10:31-54.
Hutchens et al. (1997) Molecular Biology of the Cell 8:481-500.
Ishizaki et al. (1997) FEBS Letters 404:118-124.
Jin et al. (1997) J. Neurosci. 17(16):6256-6263.
Katoh et al. (1998) J. Biol. Chem. 273(5):2489-2492.
Laudanna et al. (1996) Science 271:981-983.
Luo et al. (1996) Nature 379:837-840.
Luo et al. (1994) Genes & Development 8:1787-1802.
Matsui et al. (1996) The EMBO Journal 15(9):2208-2216.
Morii et al. (1995) Methods in Enzymology 256:196-206.
Nobes et al. (1995) Cell 81:53-62.
Somlyo (1997) Nature 389:908-911.
Song et al. (1998) Science 281:1515-1518.
Tigyi et al. (1996) Journal of Neurochemistry 66(2):537-548.
Udagawa et al. (1996) J. Biol. Chem. 271(21):12542-12548.
Uehata et al. (1997) Nature 389:990-994.
Van Leeuwen et al. (1997) J. Cell. Biol. 139(3):797-807.
Yermian et al. (1987) Nucleic Acids Research 15(4):1869.
Zipkin et al. (1997) Cell 90:883-894.
Chuang et al. (1993) “GDP Dissociation Inhibitor Prevents Intrinsic and GTPase Activating Protein-stimulated GTP Hydrolysis by the Rac GTP-binding Protein”, J. of Biol. Chem. 268(2):775-778.
Crutcher et al. (1986) “The Role of Growth Factors in Neuronal Development and Plasticity”, CRC Crit. Rev. in Neurobiol. 2(3):297-333.
Lamoureaux et al. (1997) “Rac is required for growth cone function but not neurite assembly”, J. of Cell Science 110:635-641.
Luo et al. (1997) “Rho family small GTP-binding proteins in growth cone signalling”, Current Opinion in Neurobiology 7:81-86.
Malosio et al. (1997) “Differential Expression of Distinct Memebers of Rho Family GTP-Binding Proteins . . . Family”, J. of Neuroscience 17(17):6717-6728.
Nishiki et al. (1990) “ADP-Ribosylation of therho/racProteins Induces Growth Inhibition, . . . Cultured PC-12 Cells”. Biochem. And Biophys. Res. Comm. 167(1):265-272.
Schwab et al. (1993) “Inhibitors of Neurite Growth”, Ann. Rev. of Neurosci. 16:565-595.
Kozma et al. (1997) “Rho family GTPases and neuronal growth cone remodelling: Relationship between . . . acid”, Molecular and Cellular Biology 17(3):1201-1211.
Martin F.B.G. Gebbink et al. (1997) “Identification of a novel, putative rho-specific GDP/GTP exhange factor and a rhoA-binding protein: control of neuronal morphology”, J. of Cell Biology 137(7):1603-1613.
Nikolic et al. (1998) “The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity”, Nature 395:194-198.
Bartsch et al., “Lack of Evidence That Myelin-Associated Glycoprotein Is a Major Inhibitor of Axonal Regeneration in the CNS”, Neuron, 15:1375-1381 (1995).
Barinaga, “Old Protein Provides New Clue To Nerve Regeneration Puzzle”, Science, New Series, 265(5180):1800-1801 (1994).
Braun et al., “Laminin Overrides the Inhibitory Effects of Peripheral Nervous System and Central Nervous System Myelin-Derived Inhibitors of Neurite Growth” J. Neurosci. Res., 42:594-602 (1995).
Caroni et al., “Antibody against Myelin-Associated Inhibitor of Neurite Growth Neutralizes Nonpermissive Substrate Properties of CNS White Matter”, Neuron, 1(1):85-96 (1988).
Caroni et al., “Two Membrane Protein Fractions from Rat Central Myelin with Inhibitory Properties for Neurite Growth and Fibroblast Spreading” J. Cell Biol., 106:1281-1288 (1988).
Daniels et al., “Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells”, The EMBO J., 17(3):754-764 (1988).
Davies et al., “Regeneration of adult axons in white matter tracts of the central nervous system”, Nature 390:680-682 (1997).
Kamata et al., “Morphological Effects, Rate of Incorporation, and the Enzymatic Action of Botulinum ADP-Ribosyltransferase, Known as C3 Exoenzyme, of Human Neuroblastoma GOTO Cells,”, Microbiol. Immunol., 38(6):421-428 (1994).
Lehmann et al., “Inactivation of Rho Signaling Pathway Promotes CNS Axon Regeneration”, J. Neurosci., 19(17):7537-7547 (1999).
Li et al., β- endorphin omission analogs; Dissociation of immunoreactivity from other biological activities Proc., Natl. Acad. Sci. USA, 77(6):3211-3214 (1980).
Liuzzi et al., “Peripheral Nerve Regeneration”, Neurosurgery Clinics of North America, 2(1):31-42 91991).
McKerracher et al., “Identification of Myelin-Associated Glycoprotein as a Major Myelin-Derived Inhibitor of Neurite Growth”, Neuron, 13:805-811 (1994).
Mattison et al., “Cerebrovascular Diseases: Eighteenth Princeton Conference”, Stroke 24(12):I-136-I-140; and Discussion, pp. I-144-I-145.
Nemoto et al., “Clostridium botulinum C3 ADP-ribosyltransferase Gene”, J. Biol. Chem., 266(29):19312-19319 (1991).
Saito et al., “Identification of Glu173as the critical amino acid residue for the ADP-ribosyltransferase activity ofClostridium botulinumC3 exoenzyme”, FEBS Letters 371:105-109 (1995).
Olson, “Reparative Strategies in the Brain; Treatment Strategies Based on Trophic Factors and Cell Transfer Techniques”, Acta Neurochir. (suppl) 58:3-7 (1993)
Olson et al., “Role of growth factors in degeneration and regeneration in the central nervous system; clinical experiences with NGF in Parkinson's and Alzheimer's diseases”, J. Neurol., 241:S12-S15 (1994).
Rubin et al., “Inhibition of PC12 Cell Attachment and Neurite Outgrowth by Detergent Solubilized CNS Myelin Proteins”, Eur. J. Neurosci., 7:2524:2529 (1995).
Schwab et al., “Inhibitory influences”, Nature, 371:658-659 (1994)..
Tomaselli et al., “N Neuronal Cell Line (PC12) Expresses Two β1-Class Integrins—α1β1and α3β1- That Recognize Different Neurite Outgrowth-Promoting Domains in Laminin”, Neuron, 5:651-662 (1990).
Lehmann Maxime
McKerracher Lisa
Fish & Richardson P.C.
Turner Sharon
Universite de Montreal
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