Trans-(+)-2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)c

Details Trans-(+)-2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)c Trans-(+)-2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)c

1985-10-25

1987-05-05

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61U 3141

Patent

active

046633359

ABSTRACT:
The trans(+)-2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]a cetamide enantiomer, and salts thereof, have been found to be useful as Central Nervous System anti-seizure drugs, at reasonable dosages in warm-blooded animal patients, including humans, as determined in a standard anti-convulsant laboratory animal tests.

REFERENCES:
patent: 4098904 (1978-07-01), Szmuszkovicz
patent: 4145435 (1979-03-01), Szmuszkovicz
F. C. Tortella et al, Neuroscience Abstracts, 10, p. 408, (Oct. 1984).
C. R. Randall et al, J. Med. Chem., (1984), 27, pp. 779-782.
R. P. Simon et al, Science, 226, (Nov. 1984), pp. 850-852.
E. F. Berman et al, Neuropharmacology, 23, No. 3, pp. 367-371 (1984).
The Merck Index, 10th Edit. (1983), p. 1054, item 7204.

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