Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1993-11-12
1995-04-18
Kumar, Shailendra
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
5142275, 5142378, 5142395, 514255, 514329, 514478, 514567, 514596, 544 59, 544164, 544382, 546224, 560 27, 562452, 564 47, 564 48, 564 52, 564 53, 564 54, A61K 3117, C07C27506, C07C27530
Patent
active
054079594
ABSTRACT:
Compounds of structure ##STR1## where W is selected from the group consisting of ##STR2## where Q is oxygen or sulfur, R.sup.7 and R.sup.8 are independently selected from hydrogen and alkyl, or R.sup.7 and R.sup.8, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## L.sup.1 and L.sup.2 are independently selected from a valence bond, alkylene, propenylene, and propynylene; R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is oxygen, >NR.sup.11, where R.sup.11 is hydrogen or alkyl, or ##STR4## where n=0, 1, or 2; and R.sup.5 and R.sup.6 are alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
REFERENCES:
patent: 4289903 (1981-09-01), Spatz et al.
patent: 5015762 (1991-05-01), Schirmer et al.
C. Crawley, et al., J. Med. Chem., 1992, 35, 2600-2609.
Basha Anwer
Black Lawrence A.
Chernesky Linda J.
Dellaria Joseph F.
Lee Wendy
Abbott Laboratories
Janssen Jerry F.
Kumar Shailendra
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