Tranes-delta 2-prostaglandins

Details Tranes-delta 2-prostaglandins Tranes-delta 2-prostaglandins

1964-12-19

1977-05-17

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260240R, 2603457, 2603458, 2603473, 2603479, 260470, 260473A, 260514D, 424305, 424308, 260520B, 424317, C07C17700

Patent

active

040241742

ABSTRACT:
Trans-.DELTA..sup.2 -prostaglandin compounds are disclosed of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## R.sup.1 represents an alkyl group containing from 1 to 10 carbon atoms, or an alkyl group containing from 1 to 6 carbon atoms carrying a phenyl substituent or a cycloalkyl substituent of 5 to 7 carbon atoms, R.sup.2 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, and R.sup.3.sup.' represents a hydrogen atom or an alkyl group containing from 1 to 12 carbon atoms, the double bonds in the 2- and 5-positions being in the trans- and cis-configurations respectively. These compounds are indicated in the management of conditions such as autoimmune conditions, e.g. rheumatoid arthritis.

REFERENCES:
Nelson, J. Med. Chem. 17, 913 (1974).

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