Tramadol N-oxide material, enantiomers and compositions thereof,

Details Tramadol N-oxide material, enantiomers and compositions thereof, Tramadol N-oxide material, enantiomers and compositions thereof,

1991-09-13

1993-06-29

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514850, 514867, 564299, A61K 3113, C07C29100

Patent

active

052235416

ABSTRACT:
This invention relates to a tramadol N-oxide material, enantiomers and compositions thereof and their use. The tramadol N-oxide material and compositions thereof are pharmacologically useful in treating pain, diarrhea and tussive conditions. The tramadol N-oxide is also subject to less side-effects as compared to pure opiate based compositions, such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, the tramadol N-oxide material when administered orally exhibits analgesia for a longer duration than an equi-analgesic amount of tramadol.

REFERENCES:
patent: 3652589 (1972-03-01), Flick et al.

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