Tramadol-based medicament

Details Tramadol-based medicament Tramadol-based medicament

2003-08-15

2009-11-03

Kim, Jennifer M (Department: 1617)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C514S554000, C514S650000

Reexamination Certificate

active

07611730

ABSTRACT:
The invention relates to a medicament containing the racemate of tramadol in a retarded form and the (+)-enantiomer of tramadol in a non-retarded form.

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“Complementary And Synergistic Antinociceptive Interaction Between The Enantiomers Of Tramadol”, Raffa et al., Journal of Pharmacology and Experimental Therapeutics, 1993, 267(1), 331-40.
“Analgesic Efficacy And Safety Of Tramadol Enantiomers In Comparison With The Racemate: A Randomised, Double-Blind Study With Gynaecological Patients Using Intravenous Patient-Controlled Analgesia”, Ground et al., Pain, Elsevier Science Publishers, vol. 62, No. 3, 1995.
“Tramadol Induces Antidepressant-Type Effects In Mice”, Rojas-Corrales et al., Life Sciences, vol. 63, No. 12, 1998.
Arzneim.-Forschung. Drug Res. 28, 1978, pp. 114-121.

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