TRAF2-associated protein kinase and assays

Details TRAF2-associated protein kinase and assays TRAF2-associated protein kinase and assays

1999-11-05

2000-08-22

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

530350, C12N 912, C07K 100

Patent

active

061070742

ABSTRACT:
The invention provides methods and compositions relating to a novel human tumor necrosis factor receptor associated factor number two associated kinase protein. The invention provides hybridization probes and primers capable of hybridizing with the disclosed gene, nucleic acids encoding the kinase, methods of making the kinase proteins, and methods of using the compositions in diagnosis and drug screening.

REFERENCES:
Kentrup et al. (1996) J. Biol. Chem 271, 3488-3495; "Dyrk, a Dual Specificity Protein Kinase with Unique Structural Features Whose Activity is Dependent on Tyrosine Residues between Subdomains VII and VIII"; see Figs. 1 and 2 of sequence data.
Cheng et al. Isolation and mapping of human chromosome 21 cDNA. Genomics 23, 75, 1994.
Frohman, M. in PCR Protocols: A Guide to Methods and Applications (1990) Innis, et al. Eds. pp. 28-38, Academic Press, Inc. San Diego Calif.

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