Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-02-09
2000-05-16
Scheiner, Laurie
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 723, 436501, G01N 33567
Patent
active
060635851
ABSTRACT:
The invention concerns novel inhibitors of tumor necrosis factor receptor associated factor(TRAF) mediated signal transduction. The invention encompasses the novel inhibitor proteins (I-TRAFs), nucleic acid encoding them, methods for their recombinant production, and their use in screening assays and as pharmaceuticals.
REFERENCES:
patent: 4861587 (1989-08-01), Urbaschek et al.
Kohno et al., "A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor" Proc. Natl. Acad. Sci. USA 87:8331-8335 (1990).
Laegreid et al., "Tumor necrosis factor receptor p75 mediates cell-specific activation of nuclear factor kB and induction of human cytomegalovirus enhancer" Journal of Biological Chemistry 269:7785-7791 (1994).
Laherty et al., "The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kB" Journal of Biological Chemistry 267:24157 (1992).
Landschulz et al., "The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins" Science 204:1759-1764 (1988).
Lenardo and Baltimore, "NF-.kappa.B: A pleiotropic mediator of inducible and tissue-specific gene control" Cell 58:227-229 (1989).
Lewis et al., "Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific" Proc. Natl. Acad. Sci. USA 88:2830-2834 (1991).
Liou and Baltimore, "Regulation of the NF-kB/rel transcription factor and 1kB inhibitor sysstem" Curr. Opin. Cell Biol. 5:477-487 (1993).
Loetscher et al., "Molecular Cloning and Expression of the Human 55 kd Tumor Necrosis Factor Receptor" Cell 61:351-359 (Apr. 20, 1990).
Mardon and Page, "The sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers" Cell 56:765-770 (1989).
Miller et al., "Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus Oocytes" EMBO Journal 4(6):1609-1614 (1985).
Miyatake et al., "Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes" EMBO Journal 4:2561-2568 (1985).
Mosialos et al., "The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family" Cell 80:389-399 (1995).
Naume, B. et al., "Involvement of the 55- and 75-kDa tumor necrosis factor receptors in the generation of lymphokine-activated killer cell activity and proliferation of natural killer cells" J. Immunol. 146:3035-3048 (1991).
Neta et al., "Comparison of the In Vivo effects of rIL-1 and rTNF in radioprotection, induction of CSF and of acute phase reactants" Fed. Proc. (Abstract) 46(4):1200 (1987).
Neta et al., "Interdependence of the radioprotective effects of human recombinant interleukin 1.alpha., tumor necrosis factor .alpha., granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor" J. Immunol. 140(1):108-111 (1988).
Neta et al., "Interleukin 1 is a radioprotector" J. Immunol. 136(7):2483-2485 (Apr. 1, 1986).
Nietfeld et al., "Second-order repeats in xenopus laevis finger proteins" J. Mol. Bil. 208:639-659 (1989).
Nophar et al., "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor" EMBO Journal 9:3269-3278 (1990).
Old, L.J., "Tumor Necrosis Factor" Sci. Am. 258(5):59-75 (1988).
Opipari et al., "The A20 cDNA induced by tumor necrosis factor .alpha. encodes a Novel type of zinc finger protein" Journal of Biological Chemistry 265:14705-14708 (1990).
Patarca et al., "rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1" Proc. Natl. Acad. Sci. USA 85:2733-2737 (1988).
Pennica et al., "Human Tumour Necrosis Factor: Precursor Structure, Expression and Homology to Lymphotoxin" Nature 312:724-729 (1984).
Reddy et al., "A novel zinc finger coiled-coil domain in a family of nuclear proteins" Trends Biochem. Sci. 17:344-345 (1992).
Rothe et al., "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction [C [C [C" Proceedings of the Nation Academy of Sciences 93(16):8241-8246 (1996).
Rothe et al., "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDA tumor necrosis factor receptor" Cell 78:681-692 (1994).
Rothe et al., "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins" Cell 83(7):1243-1252 (1995).
Rowe et al., "Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1: a B-cell-specific response that is delayed relative to NF-kB activation and to induction of cell surface markers" Journal of Virology 68:5602 (1994).
Ruiz i Altaba et al., "Xfin: an embryonic gene encoding a multifingered protein in Xenopus" EMBO Journal 6(10):3065-3070 (1987).
Sambrook et al. Molecular Cloning, A Laboratory Manual Chapter 16:16.3-16.81 (1989).
Schall et al., "Molecular Cloning and Expression of a Receptor for Human Tumor Necrosis Factor" Cell 61:361-370 (Apr. 20, 1990).
Schatz et al., "The V(D)J recombination activating gene, RAG-1" Cell 59:1035-1048 (1989).
Schindler and Baichwal, "Three NF-kB binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression" Molecular & Cellular Biology 14(9):5820-5831 (1994).
Shalaby et al., "Binding and regulation of cellular functions by monoclonal antibodies against human tumor necrosis factor receptors" Journal of Experimental Medicine 172:1517-1520 (1990).
Smith and Johnson, "Single-step purification of polypeptides expressed in escherichia coli as fusions with glutathione S-transferase" Gene 67:31-40 (1988).
Smith et al., "A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins" Science 248:1019-1023 (May 25, 1990).
Smith et al., "The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death" Cell 76:959-962 (1994).
Song et al., "The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation" Proceedings of the National Academy of Sciences 93(13):6721-6725 (1996).
Stanley et al., "The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promoters" EMBO Journal 4:2569-2573 (1985).
Takahashi et al., "Developmentally regulated expression of a human "finger"--containing gene encoded by the 5' half of the ret transforming gene" Molecular & Cellular Biology 8(4):1853-1856 (1988).
Tartaglia and Goeddel, "Two TNF receptors" Immunology Today 13:151-153 (1992).
Tartaglia et al., "Stimulation of human T-cell proliferation by specific activation of the 85-kDA tumor necrosis factor receptor" Proc. Natl. Acad. Sci. USA 151:4637-4641 (1993).
Tartaglia et al., "The two different receptors for tumor necrosis factor mediate distinct cellular responses" Proc. Natl. Acad. Sci. USA 88:9292-9296 (1991).
Thanos and Maniatis, "NF-kB: A lesson in family values" Cell 80:529-532 (1995).
Tomita et al., "The neurospora uvs-2 gene encodes a protein which has homology to yeast RAD18, with unique zinc finger motifs" Mol. Gen. Genet. 238:225-233 (1993).
Urbaschek et al., "Tumor necrosis factor induced stimulation of granulopoiesis and radioprotection" Lymphokine Research 6(3):179-186 (1987).
Vinson et al., "Scissors-grip model for DNA recognition by a family of leucine zipper proteins" Science 246:911-916 (1989).
Wiegmann et al., "Human 55-kDa receptor for tumor necrosis factor coupled to signal transduction cascades" Journal of Biological Chemistry 267:17997-18001 (1992).
EMBL Sequence Database Accession No. U51907 (Mar. 20, 1996).
Pharmacia Catalog pp. 133, 142-143 (1994).
Clonetech Catalog pp. 19, 192-194 (1994).
Ausubel et al., "Introduction of
Goeddel David V.
Rothe Mike
Dreger Ginger
Genetech, Inc.
Marschang Diane L.
Scheiner Laurie
Tularik Inc.
LandOfFree
TRAF Inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with TRAF Inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and TRAF Inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-257520