TRAF family proteins

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S388100, C530S389100, C435S326000, C435S346000

Reexamination Certificate

active

09706325

ABSTRACT:
In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention TPBDs. Such TPBDs and/or anti-TPBD antibodies are useful for discovery of drugs that suppress autoimmunity, inflammation, allergy, allograph rejection, sepsis, and other diseases.

REFERENCES:
patent: 6441140 (2002-08-01), Comb et al.
patent: 2002/0044941 (2002-04-01), Rosen et al.
patent: WO96/20723 (1996-07-01), None
Abstract of Inoue, WO 97/38099, Oct. 16, 1997.
MacLachlan et al, Journal of Cellular Biochemistry, 1998, vol. 71, pp. 467-478.
Seaver (Genetic Engineering News 1994 vol. 14, No. 14: pp. 10 and 21).
Everett et al (The EMBO Journal, 1997, vol. 16, pp. 1519-1530).
Brodeur et al (Journal of Biological Chemistry, 1997, vol. 272, pp. 19777-19784).
Campbell (Monoclonal Antibody Technology, 1985, pp. 1-32).
Paul (Fundamental Immunology, 1993, text, pp. 460-461).
EMBL: Accession No. AJ000644.
GenBank: Accession No. AB020705.
Arch et al., “Tumor necrosis factor receptor-associated factors (TRAFs)-a family of adapter proteins that regulates life and death”Genes Devel, 12: 2821-2830 (1998).
Borden K., “Ring fingers and B-boxes: zinc-binding protein-protein interaction domains,”Biochem. Cell. Biol.76:351-358 (1998).
Boucher et al., “Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily”Biochem. Biophys. Res. Comm., 233: 592-600 (1997).
Crowe et al., “A metalloprotease inhibitor blocks shedding of the 80D TNF receptor and TNF processing in T lymphocytes”J. Exp. Med., 181: 1205-1210 (1995).
Mosialos et al., “The Epstein-Barr Virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family”Cell, 80:389-399 (1995).
Nagai et al., “Identification of a novel nuclear speckle-type protein, SPOP”FEB Lett., 418:23-26 (1997). (Also see GenBank Accession No. NM—003563).
Nagase et al., “Prediction of the coding sequences of unidentified human genes, XII. the complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”DNA Res., 5:355-364 (1998).
Nakano et al., “TRAF5, an activator of NF-κB and putative signal transducer for the lymphotoxin-β receptor”J. Biol. Chem., 271:14661-14664 (1996).
Park et al., “Structural basis for self-association and receptor recognition of human TRAF2”Nature, 398:533-538 (1999).
Pullen et al., “CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization”Biochemistry., 37:11836-11845 (1998).
Rabizadeh et al., “Expression of the low-affinity nerve growth factor receptor enhances β-amyloid peptide toxicity”Proc. Natl. Acad. Sci. USA, 91:10703-10706 (1994).
Rothe et al., “A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor”Cell, 78:681-692 (1994).
Rothe et al., “TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40”Science, 269:1424-1427 (1995).
Rothe et al., “I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction”Proc. Natl. Acad. Sci. USA, 93:8241-8246 (1996).
Sato et al., “FAP-1: A protein tyrosine phosphatase that associates with Fas”Science, 268:411-415 (1995).
Sato et al., “A novel member of the TRAF family of putative signal transducing proteins binds to the cytocolic domain of CD40”FEBS Lett., 358:113-118 (1995).
Song and Donner, “Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor”Biochem. J., 309:825-829 (1995).
Takayama et al., “Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity”Cell, 80:279-284 (1995).
Tatusova and madden et al., “BLAST 2 sequences, a new tool for comparing protein and nucleotide sequences”FEMS Microbiol Lett., 174:247-250 (1999).
Wajant et al., “Identification of a TRAF (TNF receptor-associated factor) gene inCaenorhabditis elegans” J. Mol. Evol., 47:656-662 (1998).
Wajant et al., “TNF receptor associated factors in cytokine signaling”Cytokine Growth Factor Rev., 10:15-26 (1999).
Ye et al., “The structural basis for the recognition of diverse receptor sequences by TRAF2”Mol. Cell.4:321-330 (1999).
Dadgostar and Cheng, “An intact zinc ring finger is required for tumor necrosis factor receptor-associated factor-mediated nuclear factor-κB activation but is dispensable for c-Jun N-terminal kinase signaling”J. Biol. Chem., 273:24775-24780 (1998).
Darnay et al., “Activation of NF-κB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-κB-inducing kinase”J. Biol. Chem., 274:7724-7731 (1999).
Everett et al., “A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein”EMBO J., 16:566-577 (1997). (Also see GenBank Accession No. Z72499).
Force et al., “Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-β receptor”J. Biol. Chem., 272:30835-30840 (1997).
Gedrich et al., “CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins”J. Biol. Chem., 271:12852-12858 (1996).
Gene/protein characteristic table for KIAA0898, http://zearth.kazusa.or.jp/huge/gfpage/KIAA0898, as of Oct. 5, 1999 (Also see GenBank Accession No. AB020705).
Hanada et al., “Structure-function analysis of Bcl-2 protein”J. Biol. Chem.270:11962-11969 (1995).
Hostager and Bishop, “Cutting Edge: Contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiation”J. Immunol., 162:6307-6311 (1999).
Ishida et al., “Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region”J. Biol. Chem., 271:28745-28748 (1996).
Krajewska et al., “TRAF-4 expression in epithelial progenitor cells”Am. J. Pathol., 152:1549-1561 (1998).
Krajewski et al., “Detection of multiple antigens on western blots”Anal. Biochem., 236:221-228 (1996).
Kwon et al., “Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand”J. Biol. Chem., 274:6056-6061 (1999).
Leo et al., “Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-κB and Jun N-terminal kinase activation”J. Biol. Chem., 274:22414-22422 (1999).
Lin and Stavnezer, “Activation of NF-κB/Rel by CD40 engagement induces the mouse germ line immunoglobulin CΥ1 promoter”Mol. Cell. Biol., 16:4591-4603 (1996).
Liu et al., “ADrosophilaTNF-receptor-associated factor (TRAF) binds the Ste20 kinase Misshapen and activates Jun kinase”Curr. Biol.9:101-104 (1999).
MacFarlane et al., “Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL”J. Biol. Chem., 272:25417-25420 (1997).
Miyashita and Reed, “Tumor suppressor p53 is a direct transcriptional activator of the human bax gene”.Cell80:293-299 (1995).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

TRAF family proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with TRAF family proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and TRAF family proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3771630

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.