Tracheal antimicrobial peptides, DNA sequences and methods for t

Details Tracheal antimicrobial peptides, DNA sequences and methods for t Tracheal antimicrobial peptides, DNA sequences and methods for t

1990-10-25

1993-04-13

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 514 12, C07K 710, A61K 3702

Patent

active

052024202

ABSTRACT:
The present invention provides a new class of polypeptides with antimicrobial activity, termed "tracheal antimicrobial peptides," cDNA sequences encoding for the peptides and methods for the production and use thereof.

REFERENCES:
patent: 4677063 (1987-06-01), Mark et al.
patent: 4705777 (1987-11-01), Lehrer et al.
patent: 5028530 (1991-07-01), Lai et al.
patent: 5032574 (1991-07-01), Wilde et al.
Bowman, H. G. and D. Hultmark, Ann. Rev. Microbiol., 41:103-126 (1987).
Soravia, E., G. Martini et al., "Antimicrobial properties of peptides from Xenopus granular gland secretions," FEBS Lett., 228:337-40 (1988).
Zasloff, M. A., "Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor," Proc Natl Acad Sci USA, 84:5449-5453 (1987).
Gabay, J. E., "Microbicidal mechanisms of phagocytes," Curr Opin Immunol, 1(1):36-40 (1988).
Gabay, J. E., R. W. Scott et al., "Antibiotic proteins of human polymorphonuclear leukocytes," Proc Natl Acad Sci USA, 86(14):5610-4 (1989).
Ganz, T., "Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes," Infect Immun, 55(3):568-71 (1987).
Ganz, T., J. A. Metcalf et al., "Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and `specific` granule deficiency," J Clin Invest, 82(2):552-6 (1988).
Ganz, T., J. R. Rayner et al., "The strucure of the rabbit macrophage defensin genes and their organ-specific expression," J Immunol, 143(4):1358-65 (1989).
Ganz, T., M. E. Selsted et al., "Defensins," Eur J Haematol, 44(1):1-8 (1990b).
Ganz, T., M. E. Selsted et al., "Defensins, Natural peptide antibodies of human neutrophils," J Clin Invest, 76(4):1427-35 (1985).
Ouellette, A. J., R. M. Greco et al., "Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium," J Cell Biol, 108(5):1687-95 (1989).
Bevins, C. L. and M. A. Zasloff, "Peptides from frog skin," Ann. Rev. Biochem., 59:395-414 (1990).
Kagan, B. L., M. E. Selsted et al., "Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes," Proc Natl Acad Sci USA, 87(1):210-4 (1990).
Lehrer, R. I., A. Barton et al., "Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity," J Clin Invest, 84(2):553-61 (1989).
Romeo D., B. Skerlavaj et al., "Structure and bacericidal activity of an antibiotic dodecapeptide purified from bovine neutrophils," J Biol Chem, 263:9573-75 (1988).
Matsuyama, K. and Natori, S., "Purification of three antibacterial proteins from the culture medium of NIH-Sape-4, an embryonic cell line of Saroophaga peregrina," J biol Chem, 263:17112-16 (1988).
Fujiwara, S., J. Imai et al., "A potent antimicrobial protein in royal jelly," J Biol Chem, 265:11333-37 (1990).
Bolivar, et al., Gene (1977) 2:95.
Selsted M. E., S. S. Harwig et al., "Primary structures of three human neutrophil defensins," J Clin Invest, 76(4):1436-9 (1985).
Wilde, C. G., J. E. Griffith, et al., "Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family," J Biol Chem, 264(19):11200-3 (1989).
Steiner, H. D., Hultmark, A. et al., "Sequence and specificity of two antibacterial proteins involved in insect immunity," Nature, 292:246-248 (1981).
R. T. Ellison III et al., "Isolation of an Antibacterial Peptide from Human Lung Lavage Fluid", The Journal of Infectious Diseases, vol. 151, No. 6, Jun., 1985 pp. 1123-1129.

Affiliated with

Also associated with

Rating

Tracheal antimicrobial peptides, DNA sequences and methods for t does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tracheal antimicrobial peptides, DNA sequences and methods for t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tracheal antimicrobial peptides, DNA sequences and methods for t will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1156273