Tr3-specific binding agents and methods for their use

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007210, C435S007230, C435S007240, C530S387100, C530S388100, C530S389100, C514S002600

Reexamination Certificate

active

06994976

ABSTRACT:
Biologically active TR3-specific binding agents and methods for their use are disclosed. The biologically active TR3-specific binding agents are useful for inhibiting the proliferation of cells expressing TR3. These biologically active agents are particularly useful for treating T-cell mediated diseases such as graft-versus-host disease, organ rejection, tumor growth, autoimmunity, and inflammation.

REFERENCES:
patent: 6462176 (2002-10-01), Ashkenazi
patent: WO 97 33904 (1997-09-01), None
patent: WO 97 37020 (1997-10-01), None
patent: WO 98 05783 (1998-02-01), None
patent: WO 99/19490 (1999-04-01), None
patent: WO 00 64465 (2000-11-01), None
Screaton, G. et al. Proc. Nat. Acad. Sci. 1997, vol. 94, pp. 4615-1619.
Chicheportiche, Y., et al., “TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly inducus apoptosis” (1997)J. Bio Chem.272(51): 32401-32410.
Chicheportiche, Y., et al., “Proinflammatory activity of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK monoclonal antibodies” (2002)Arthritis Res.4(2): 126-133.
Donohue, P.J., et al., “TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity” (2003)Arterioscler. Thromb Vasc. Biol.23(4): 594-600.
Kaplan, M.J., et al., “TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand)mediate CD4+T cell killing of antigen-presenting macrophages”J. Immunol164(6): 2897-2904.
Kaptein, A., et al., “Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)” (2000)FEBS lett.485(2-3): 135-141.
Marsters, S. A., et al., “Identification of a ligand for the death-domain-containing receptor Apo3” (1998)Curr Biol.8(9): 525-528.
Nakayama, M., et al., “Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies” (2003)Biochem Biophys Res Commun306(4): 819-825.
Polek., et al. “TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TWEAKR. Evidence for a second TWEAK receptor” (2003)J. Bio Chem.
Schneider, P., et al., “TWEAK can induce cell death via endogenous TNF and TNF receptor 1” (1999)Eur J Immunol29(6): 1785-1792.
Wiley, S.R., et al., “A novel TNF receptor family member binds TWEAK and its implicated in angiogenesis” (2001)Immunity15(5): 837-846.
International Search Report dated May 10, 2001.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Tr3-specific binding agents and methods for their use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tr3-specific binding agents and methods for their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tr3-specific binding agents and methods for their use will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3707974

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.