TPO peptide compounds for treatment of anemia

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S002600, C514S013800, C514S014800, C514S015800, C514S017400, C530S300000, C530S324000, C530S325000, C530S326000, C530S327000

Reexamination Certificate

active

07615533

ABSTRACT:
Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.

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Case B.C. et al: “The pharmacokinetics and pharmacodynamics of GW39505, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia” Stem Cells, Alphamed Press, Dayton, Oh, vol. 18, No. 5, 2000, pp. 360-365, XP002421199, ISSN: 1066-5099.
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Singer S.C. et al.: “Pegylated thrombopoietin (TPO)-Mimetic peptides bind human to TPO receptor causing proliferation and maturation of megakaryocytes in vitro” Blood, W.B. Saunders Company, Orlando, FL, US, vol. 92, No. 10 Suppl PT1-2, Nov. 15, 1998, p. 568A, XP009079489.
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