Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Protozoa – media therefor
Reexamination Certificate
2005-06-07
2005-06-07
Navarro, Mark (Department: 1645)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Protozoa, media therefor
C435S006120, C435S069100, C435S069700, C536S023400, C536S023700, C424S273100, C424S266100, C424S265100, C424S185100
Reexamination Certificate
active
06902926
ABSTRACT:
The invention provides polypeptide fragments derived from TgAMA-1, nucleic acids that encode the polypeptide fragments, and TgAMA-binding polypeptides such as antibodies. Methods for using the polypeptide and nucleic acid molecules to produce vaccines are also provided. In addition the invention provides methods involving use of the polypeptides, nucleic acids, and binding polypeptides, such as antibodies, for the prevention and treatment of Toxoplasmosis.
REFERENCES:
patent: 5101017 (1992-03-01), Rubinstein et al.
patent: 6066623 (2000-05-01), Hoffman et al.
patent: 6120770 (2000-09-01), Adams et al.
Rudinger et al, in “Peptide Hormones”, edited by Parsons, J.A., University Park Press, Jun. 1976, p. 6).
Burgess et al., The Journal of Cell Biology, 111:2129-2138, 1990).
Lazar et al., Molecular and Cellular Biology, 8(3): 1247-1252, 1988.
Jobling et al. (Mol. Microbiol. 1991, 5(7): 1755-67.
Ellis, R.W. (Chapter 29 of “VACCINES” Plotkin, 5.A. et al. (eds) published by W. B. Saunders company (Philadelphia) in 1988, especially p. 571.
Hehl et al, Infection and Immunity, Dec. 2000, p. 7078-7086, vol. 68, No. 12.
Hehl et al 1997, Acession No.: AF010264.
Hehl et al Acession No.: O15981, 1998.
Bercovici, T. et al., “5-[125I]Iodonaphthyl Azide, a Reagent to Determine the Penetration of Proteins into the Lipid Bilayer of Biological Membranes”,Biochemistry, Apr. 18, 1978, pp. 1484-1489, vol. 17, No. 8.
Brydges, S.D. et al., “Molecular characterization of TgMIC5, a proteolytically processed antigen secreted from the micronemes ofToxoplasma gondii”, Molecular and Biochemical Parasitology, 2000, pp. 51-66, vol. 111, Elsevier Science B.V.
Carey, K.L. et al., “Identification and molecular characterization of GRA8, a novel, proline-rich dense granule protein ofToxoplasma gondii”, Molecular and Biochemical Parasitology, 2000, pp. 25-37, vol. 105, Elsevier Science B.V.
Carruthers, V.B. et al., “Mobilization of intracellular calcium stimulates microneme discharge inToxoplasma gondii”, Molecular Microbiology, 1999, pp. 421-428, vol. 31, No. 2, Blackwell Science Ltd.
Carruthers, V.B. et al., “Ethanol and acetaldehyde elevate intracellular [Ca2+] and stimulate microneme discharge inToxoplasma gondii”, Biochem. J., 1999, pp. 379-386, vol. 342, Biochemical Society Great Britain.
Carruthers, V.B. et al., “Secretion of micronemal proteins is associated with toxoplasma invasion of host cells”,Cellular Microbiology, 1999, pp. 225-235, vol. 1, No. 3, Blackwell Science Ltd.
Carruthers, V.B. et al., “TheToxoplasmaAdhesive Protein MIC2 is Proteolytically Processed at Multiple Sites by Two Parasite-derived Proteases”,The Journal of Biological Chemistry, May 12, 2000, pp. 14346-14353, vol. 275, No. 19, The American Society for Biochemistry and Molecular Biology, Inc. USA.
Chittum, H.S. et al., “Rabbit β-Globin is Extended Beyond Its UGA Stop Codon by Multiple Suppressions and Translational Reading Gaps”,Biochemistry, 1998, pp. 10866-10870, vol. 37, American Chemical Society.
Church, W.R. et al., “Monoclonal Antibodies to the Amino- and Carboxyl-Terminal Domains of Ovotransferrin”,Hybridoma, Oct. 1988, pp. 471-484, vol. 7, No. 5, Mary Ann Liebert, Inc.
Donahue, C.G. et al., “Characterization of Apical Membrane Antigen-1, AMA-1, a novel transmembrane protein ofToxoplasma gondii”, Department of Microbiology and Molecular Genetics Annual Retreat Poster, Oct. 15-16, 1999.
Donahue, C.G. et al., “TheToxoplasmahomolog ofPlasmodiumapical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elevated intracellular calcium levels”,Molecular Parasitology Meetings Poster, Woods Hole, MA, Sep. 17-21, 2000.
Donahue, C.G. et al., “TheToxoplasmahomolog ofPlasmodiumapical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elevated intracellular calcium levels”,Department of Microbiology and Molecular Genetics Annual Retreat, Oral Presentation, Oct. 7, 2000.
Donahue, C.G. et al., “TheToxoplasmahomolog ofPlasmodiumapical membrane antigen-1 (AMA-1) is a microneme protein which is secreted from the parasite in response to elevated intracellular calcium levels”,ASCB Annual Meeting Article No. 1236, San Francisco, CA, Dec. 9-13, 2000, Molecular Biology of the Cell II.
Eng, J.K. et al., “An Approach to Correlate Tandem Mass Spectral Data of Peptides with Amino Acid Sequences in a Protein Database”,J. Am. Soc. Mass. Spectrom, 1994, pp. 976-989, vol. 5, American Society for Mass Spectrometry.
Hodder, A.N. et al., “The Disulfide Bond Structure ofPlasmodiumApical Membrane antigen-1”,The Journal of Biological Chemistry, Nov. 15, 1996, pp. 29446-29452, vol. 271, No. 46, The American Society for Biochemistry and Molecular Biology, Inc. USA.
Roos, D.S. et al., “Chapter 3: Molecular Tools for Genetic Dissection of the Protozoan ParasiteToxoplasma gondii”, Methods in Cell Biology, 1994, pp. 27-63, vol. 45, Academic Press, Inc.
Wan, K.L. et al., “Molecular characterisation of an expressed sequence tag locus ofToxoplasma gondiiencoding the micronemal protein MIC2”,Molecular and Biochemical Parasitology, 1997, pp. 203-214, vol. 84, Elsevier Science B.V.
Ward, G.E. et al., “96-Well plates providing high optical resolution for high-throughput, immunofluorescence-based screening of monoclonal antibodies againstToxoplasma gondii”, Journal of Immunological Methods, 1999, pp. 11-18, vol. 230, Elsevier Science B.V.
Conant Carolyn G.
Ward Brian
Ward Gary E.
Baskar Padma
McGill University
Navarro Mark
University of Vermont and State Agricultural College
Wolf Greenfield & Sacks P.C.
LandOfFree
Toxoplasma gondii apical membrane antigen-1 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Toxoplasma gondii apical membrane antigen-1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Toxoplasma gondii apical membrane antigen-1 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3494245