Toxoids of elastase of Pseudomonas aeruginosa origin

Details Toxoids of elastase of Pseudomonas aeruginosa origin Toxoids of elastase of Pseudomonas aeruginosa origin

1985-01-24

1986-03-11

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

260112R, 424 85, 424 88, 424 92, 424 94, 435 68, 435253, 435875, C07G 700, A61K 3940, A61K 39104, C12P 2100

Patent

active

045754594

ABSTRACT:
Provided herein are two kinds of toxoid of elastase of Pseudomonas aeruginosa origin, one of which is obtained by treating a purified elastase produced from Pseudomonas aeruginosa with a synthetic peptide for chloroacetyl-N-hydroxy-L-leucyl-L-alanylglycinamide and the other of which is obtained by treating at first with formalin, then, with the synthetic peptide. The present invention also contemplates a method for preparing the toxoids and the use of such toxoids for preventing and treating infections caused by Pseudomonas aeruginosa on human beings and mammalian animals. Acute toxicity of the toxoids is inspected.

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J. Biol. Chem., 240:3295-3304 (1965), Morihara et al.
J. Biol. Chem., 255:3482-3486 (1980), Nishino et al.

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