Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1984-09-07
1990-01-16
Teskin, Robin L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530350, 530387, 530389, 530390, 530391, 530820, 530825, 424 8591, 424 88, 424 92, 514 21, 514 2, 435 691, 435 697, A61K 3900, A61K 3902
Patent
active
048944432
ABSTRACT:
A novel class of polypeptides of the general formula (F-(Pro).sub.n).sub.m F, wherein F represents a flexible amino acid sequence wherein each amino acid is individually selected from the group consisting of serine, glycine, and threonine, and n is an integer from 4-8 inclusive and m is an integer from 1-4 inclusive, is disclosed. Thses polypeptides are useful in the construction of conjugates between antibodies and peptide toxins. The preparation of such conjugate toxins by linking antibodies to toxin/spacer composites prepared by recombinant techniques is also disclosed.
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Greenfield Lawrence I.
Kaplan Donald A.
Nitecki Danute E.
Cetus Corporation
Giotta Gregory J.
Halluin Albert P.
Murashige Kate H.
Teskin Robin L.
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