Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Patent
1996-12-03
1999-10-05
Stucker, Jeffrey
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
435 71, 435 74, A61K 3804, G01N 3353, G01N 33573
Patent
active
059626372
ABSTRACT:
A toxin assay that uses a substrate for cleavage by the toxin and antibodies that do not recognise the substrate but recognise and bind to the product of cleavage of the substrate by the toxin. The substrate can be a nerve cell peptide when the assay is for botulinum toxin or tetanus toxin.
REFERENCES:
patent: 5171662 (1992-12-01), Sharma
Oyler, G.A. et al., "The Indentification of a Novel Synaptosomal-associated Protein, SNAP-25, Differentially Expressed by Neuronal Subpopulations," J. Cell Bio . 109:3039-3052 (1989).
Schiavo et al. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin, Nature, vol. 359, pp. 832-835, see abstract, p. 832, col. 2, paragraph 1, p. 833, col. 2, paragraph 1 and Figure 3, Oct. 1992.
Sollner et al., SNAP receptors implicated in vesicle targeting and fusion, Nature, vol. 352, pp. 318-324, see abstract and Figure 3, Mar. 1993.
Foran, P. et al., "Differences in the Protease Activities of Tetanus and Botulinum B Toxins Revealed by the Cleavage of Vesicle-Associated Membrane Protein and Various Sized Fragments," Biochem . 33:15365-15374 (Dec. 27, 1994).
Rossetto, O. et al., "SNARE Motif and Neurotoxins, " Nature 372:415-416 (Dec. 1, 1994).
Shone, C. and Roberts, A., "Peptide Substrate Specificity and Properties of the Zinc-Endopeptidase Activity of Botulinum Type B Neurotoxin," Eur. J. Biochem . 225:263-270 (Oct. 1, 1994).
Hallis Bassam
James Benjamin Arthur Frederick
Quinn Conrad Padraig
Shone Clifford Charles
Microbiological Research Authority
Park Hankyel T.
Stucker Jeffrey
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