Total synthesis of galanthamine, analogues and derivatives...

Details Total synthesis of galanthamine, analogues and derivatives... Total synthesis of galanthamine, analogues and derivatives...

2006-09-19

2006-09-19

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C546S065000, C546S110000, C549S358000, C549S399000, C549S446000, C549S458000

Reexamination Certificate

active

07109327

ABSTRACT:
The invention relates to a method for the synthesis of galanthamifle, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom. R2=a hydroxy group, R1and R2together form ═O, R3, R4, and R5independently=a hydrogen atom, a hydroxy group or a (C1–C2)alkoxy group, R6═H, (C1–C12)alkyl, (CH2)nNR7R8, or —(CH2)nN′R7R8R9where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO2, or —NR6group where R6is as defined above or is an amine protecting group

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