Total synthesis of chiral 2-amino-1,3-diols

Details Total synthesis of chiral 2-amino-1,3-diols Total synthesis of chiral 2-amino-1,3-diols

1989-10-30

1991-04-30

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

548243, 552 10, 564487, 564507, 564360, C07C20942

Patent

active

050120000

ABSTRACT:
A method for the preparation of chiral 2-amino-1,3-diols is disclosed. The method involves four steps including performance of an aldol condensation with a chiral oxazolidinone on an aldehyde, treating the aldol condensation product with an alkali metal azide, treating the product with a borohydride reagent and reducing the azide to an amine.

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