Total steroid synthesis employing substituted isoxazole derivati

Details Total steroid synthesis employing substituted isoxazole derivati Total steroid synthesis employing substituted isoxazole derivati

1976-06-14

1977-08-23

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603973, 2603974, 260307H, 2603407, 2603409AS, 2603453, C07J 4300

Patent

active

040440044

ABSTRACT:
The novel intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-norsteroids. Further, the intermediates and processes of the invention provide a novel route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 19.beta.-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereospecific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

REFERENCES:
patent: 3890391 (1975-06-01), Eder et al.
patent: 3984473 (1976-10-01), Hajos

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