Total steroid synthesis employing substituted isoxazole derivati

Details Total steroid synthesis employing substituted isoxazole derivati Total steroid synthesis employing substituted isoxazole derivati

1974-06-05

1976-10-12

Raymond, Richard L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260327M, 2603407, 2603459, 260468R, 260476C, 260488B, 260586E, C07D31726

Patent

active

039857719

ABSTRACT:
The novel intermediates and processes of this invention provide a new synthetic route for the preparation of pharmaceutically valuable 19-nor-steroids. Further, the intermediates and processes of the invention provide a novel route for the preparation of pharmaceutically valuable estrones. The present invention provides a facile total synthesis of 13.beta.-alkyl-C/D-trans-steroidal materials. This desirable result is obtained via a unique asymmetric induction followed by subsequent stereo-specific reaction steps. As a precursor to the steroidal Ring A, a 3,5-disubstituted-4-isoxazolylmethylene group is employed in this synthesis.

REFERENCES:
patent: 3591606 (1971-07-01), Warnant et al.
patent: 3591607 (1971-07-01), Furst et al.

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