Total internal reflection fluorescence microscope

Details Total internal reflection fluorescence microscope Total internal reflection fluorescence microscope

2008-05-06

2008-05-06

Allen, Stephone B. (Department: 2872)

Optical: systems and elements

Compound lens system

Microscope

C359S385000, C250S458100

Reexamination Certificate

active

07369308

ABSTRACT:
A total internal reflection fluorescence microscope includes a light source which generates laser light having a plurality of wavelengths, a focal optical system which irradiates the laser light from the light source on a specimen at a predetermined incident angle via an objective lens and which generates evanescent illumination, a fluorescence observation unit which observes fluorescence generated from the specimen due to the evanescent illumination, an incident angle adjuster which adjusts the incident angle of the laser light irradiated on the specimen, and a controller which controls the incident angle adjuster such that the amount of the permeation depth of the evanescent light is the same when the wavelength of the laser light from the laser light source is switched.

REFERENCES:
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patent: 6987609 (2006-01-01), Tischer et al.
patent: 2003/0058530 (2003-03-01), Kawano
patent: 2003/0155527 (2003-08-01), Natori
patent: 2002-31762 (2002-01-01), None
patent: WO 03023483 (2003-03-01), None
Daniel Axelrod; “Total Internal Reflection Fluorescence at Biological Surfaces”; Non-Invasive Techniques in Cell Biology; 93-127; 1990 Wiley-Liss, Inc; pp. 111-113.

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