Total hemoglobin concentration measurement

Details Total hemoglobin concentration measurement Total hemoglobin concentration measurement

2000-06-16

2002-10-29

Winakur, Eric F. (Department: 3736)

Surgery

Diagnostic testing

Measuring or detecting nonradioactive constituent of body...

C600S328000, C600S331000

Reexamination Certificate

active

06473632

ABSTRACT:

FIELD OF THE INVENTION
The present invention relates generally to methods and instruments for measuring the concentration of a chromophore such as hemoglobin in tissue.
BACKGROUND OF THE INVENTION
Spectrophotometric instruments and methods for measuring the amount of a tissue chromophore having a certain functional state (e.g., the percentage of oxidized hemoglobin or StO2, and the percentage of oxidized cytochrome aa3) are generally known and disclosed, for example, in the Anderson et al. U.S. Pat. No. 5,879,294, which is hereby incorporated by reference in its entirety. The Anderson et al. patent discloses in particular a measurement algorithm which makes use of scaled second derivative spectrum values.
The Kuestner U.S. Pat. No. 5,377,674 discloses a spectrophotometric instrument and method for measuring the total concentration of a chromophore such as hemoglobin in tissue. The measurement algorithm uses a single term ratio of second derivative absorbance measured at a wavelength at which hemoglobin absorption occurs (analyte wavelength), and a second derivative absorbance measured in a wavelength region where no hemoglobin absorption occurs (reference wavelength) (e.g, 2
nd
derivative of absorbance at 1740 nm / 2
nd
derivative of absorbance at 1346 nm).
There remains, however, a continuing need for improved instruments and methods for measuring the total concentration of chromophores such as hemoglobin in tissue.


REFERENCES:
patent: 4875486 (1989-10-01), Rapoport et al.
patent: 5308982 (1994-05-01), Ivaldi et al.
patent: 5361758 (1994-11-01), Hall et al.
patent: 5377674 (1995-01-01), Kuestner
patent: 5729333 (1998-03-01), Osten et al.
patent: 5879294 (1999-03-01), Anderson et al.
patent: 5931779 (1999-08-01), Arakaki et al.
patent: 5978691 (1999-11-01), Mills
patent: 6006119 (1999-12-01), Soller et al.
patent: 0 816 829 (1998-01-01), None
PCT International Search Report PCT/US00/16589 mailed Oct. 2, 2000 (7 pages).

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