Toremifene crystallization method

Details Toremifene crystallization method Toremifene crystallization method

2008-05-06

2008-05-06

Barts, Samuel A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

10557471

ABSTRACT:
The invention relates to a method for isolating toremifene from a mixture of toremifene and its corresponding E isomer. The method comprises contacting the isomer mixture with a first solvent comprising methanol, allowing toremifene to crystallize in said first solvent, allowing the crystallized product of the previous step to crystallize from a second solvent comprising acetone, methyl ethyl ketone or ethyl acetate, and optionally converting toremifene crystallized from the previous step to a pharmaceutically acceptable salt thereof.

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patent: 5491173 (1996-02-01), Toivola et al.
patent: 6491951 (2002-12-01), Kananen et al.
patent: 165785 (1993-01-01), None
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patent: 0 158 973 (1985-10-01), None
Chemical Abstract of DK165785: 1992:489944 , 1992.
Abstract of DK 165 785 (Jan. 18, 1993).

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