Toremifene crystallization method

Details Toremifene crystallization method Toremifene crystallization method

2008-05-06

2008-05-06

Barts, Samuel A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

07368607

ABSTRACT:
The invention relates to a method for isolating toremifene from a mixture of toremifene and its corresponding E isomer. The method comprises contacting the isomer mixture with a first solvent comprising methanol, allowing toremifene to crystallize in said first solvent, allowing the crystallized product of the previous step to crystallize from a second solvent comprising acetone, methyl ethyl ketone or ethyl acetate, and optionally converting toremifene crystallized from the previous step to a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4696949 (1987-09-01), Kurkela et al.
patent: 5011771 (1991-04-01), Bellet et al.
patent: 5491173 (1996-02-01), Toivola et al.
patent: 6491951 (2002-12-01), Kananen et al.
patent: 165785 (1993-01-01), None
patent: 0 095 875 (1983-12-01), None
patent: 0 158 973 (1985-10-01), None
Chemical Abstract of DK165785: 1992:489944 , 1992.
Abstract of DK 165 785 (Jan. 18, 1993).

Affiliated with

Also associated with

Rating

Toremifene crystallization method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Toremifene crystallization method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Toremifene crystallization method will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2757820