Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-05-26
1998-11-24
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 530300, 530323, 436518, 536 231, 935 77, 935 78, C12Q 168, G01N 3353, C07K 1702, C07H 2104
Patent
active
058404856
ABSTRACT:
The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.
REFERENCES:
patent: 5182366 (1993-01-01), Heubner et al.
patent: 5288514 (1994-02-01), Ellman
Baum, 1993, Solid-phase synthesis of benzodiazepines, Chemical and Engineering News 71:33.
Brenner and Lerner, 1992, Encoded combinatorial chemistry, Proc Nat Acad Sci USA 89:5381-5383.
Bunin and Ellman, 1992, A general and expedient method for the solid-phase synthesis of 1,4 diazepine derivatives, J Am Chem Soc 114:10997-10998.
Furka et al, 1991, General method for rapid synthesis of multicomponent peptide mixtures, Int J Pept Prot Res 37:487-493.
Gallop et al., 1994, Applications of combinatorial technologies of drug discovery. 1. Background and peptide combinatorial libraries, J Medicinal Chemistry 37(9):1233-1251.
Gordon et al., 1994, Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions, J Medicinal Chemistry 37(10)1385-1401.
Kerr et al., 1993, Encoded combinatorial peptide libraries containing non-natural amino acids, J Am Chem Soc 115(6):2529-2531.
Lam et al., 1993, The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors, Bioorg Med Chem Lett 3:419-429.
Lam et al., 1991, A new type of synthetic peptide library for identifying ligand binding activity, Nature 354:82-85.
Lam and Lebl, 1992, Streptavidin and avidin recognize peptide ligands with different motifs, Immunomethods 1:1-15.
Lebl et al., 1994, Construction and Screening of Libraries of peptide and non-peptide structures, Techniques in Protein Chemistry V:541-548.
Needles et al., 1993, Generation and screening of an oligonucleotide-encoded synthetic peptide library, PNAS USA 90:10700-10704.
Nikolaiev et al., Peptide-encoding for structure determination of nonsequenceable polymers within libraries synthesized and tested of solid-phase supports, Peptide Research 6(3):161-170.
Ohlmeyer et al., 1993, Complex synthetic chemical libraries indexed with molecular tags, PNAS USA 90:10922-10926.
Simon et al., 1992, Peptoids: a modular approach todrug discovery, PNAS USA 89:9367-9371.
Vagner et al., Novel methodology for differentiation of surface and interior areas of polyoxyethylene-polystyrene (POE-PS) supports: application to library screening procedures, in "Innovationns and Perspectives in Solid Phase Synthesis and Related Technologies" (R. Epton ed.); corresponding to the Third International Symposium organized by Roger Epton. Aug. 31-Sep. 4, 1993, Oxford,England.
Kocis Peter
Krchnak Victor
Lam Kit S.
Lebl Michal
Salmon Sydney E.
Selectide Corporation
Zitomer Stephanie W.
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