Topoisomerase type II gene polymorphisms and their use in...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091200, C435S233000, C536S023200, C536S023700, C536S024320, C536S024330

Reexamination Certificate

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07135283

ABSTRACT:
Novel polymorphisms of prokaryotic topoisomerase type II Gyr A, Gyr B and parC gene loci are provided. These polymorphisms differentiate very closely related organisms and provide a means to identify pathogenicity and drug resistance. For example, drug resistance such as resistance to methicillin, a drug which is not metabolically tied to topoisomerase function, may be determined by polymorphisms in the Gyrase A locus. Identification of such drug resistance by such unrelated loci is indicative of heretofore unrecognized [sub]species ofStaphylococcus aureus.

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