Topoisomerase poisons for the treatment of proliferative...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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Details

C514S613000, C514S614000, C514S616000, C514S617000, C564S123000, C564S148000, C564S150000, C564S153000

Reexamination Certificate

active

10129936

ABSTRACT:
Methods for the treatment of a proliferative disorder are provided in which a subject in need of such treatment is administered an effective amount of a compound selected from: compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X1and X2are independently H, Cl, F, Br, I, CN, CF3or NO2, and Ar1is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; and compounds of formula (II) wherein X3and X4are each independently H, Cl, F, Br, I, CN, CF3or NO2; Y is (C2–C6)alkylene or (C2–C6)heteroalkylene; and Z is Cl, F, Br, I, CN, CF3or NO2.

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patent: WO 98/40102 (1998-09-01), None
patent: WO 98/40102 (1998-09-01), None
Parmar et al. ‘Synthesis of substituted benzylidinohydrazines and their monoamine oxidase inhibitory and Anticonvulsant properties,’ Journal of Pharmaceutical Sciences, 1975, Vo. 64, No. 1, pp. 154-157.
Sinha ‘Topoisomerase inhibitors,’ Drugs, 1995, Vo. 49, No. 1, pp. 11-19.
Dancey et al. ‘Current perspective on camptothecins in cancer treatment,’ British Journal of Cancer, 1996, vol. 74, pp. 327-338.
Kim, J. et al., “Alkylation of 4,5-Dichloropyridazan-6-one with α,ω-dibromoalkanes or 4,5-dichloro-1-(ω-bromoalkyl)pyridazin-6-ones” Heterocyclic Chem. 34(1):209-214 (1997).
Parmar, S. et al., “Synthesis of substituted benzylidinohydrazines and their monoamine oxidase inhibitory and anticonvulsant properties” Journal of Pharmaceutical Sciences 64 (1):154-157 (1975).
Santagati, N. et al., “Synthesis and pharmacological study of a series of 3(2H)-pyridazinones as analgesic and anti-inflammatory agents” Ed. Sci. 40 (12):921-929 (1985).

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