Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-10-14
2000-02-15
Myers, Carla J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 237, 536 232, 536 2432, 435183, 4353201, 4352523, 435471, 435233, 530350, C07H 2104
Patent
active
060251565
ABSTRACT:
Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase III and for detecting the polypeptide in a host.
REFERENCES:
patent: 5004758 (1991-04-01), Boehm et al.
Lerner, et al: "High Throughput Screen for Inhibitors of Bacterial DNA Topoisomerase I Using the Scintillation Proximity Assay" Journal of Biomolecular Screening, vol. 1, No. 3; pp. 135-143 (1996).
Snewin, et al.: "Cloning and Characterisation of a gene from Plasmodium vivax and P. knowlesi: homology with valine-tRNA synthetase" Gene vol. 173 No. 2 (1996) pp. 137-145.
Brown, et al: "A Sign Inversion Mechanism for Enzymatic Supercoiling of DNA" Science vol. 206, pp. 1081-1083 (1979).
Yoshimora, et al: "Bacillus subtilis secretes a foreign protein by the signal sequence of Bacillus amyloliquefaciens neutral protease" Appl. Microbiol vol. 23, pp. 250-256 (1986).
Huang, et al: "DNA Topology and Its Biological Effects" ColdSpring Harbor Laboratory Press (1990), pp. 265-284.
Kato, et al.: "Purification and Characterization of DNA Topoisomerase IV in Escherichia coli"Journal of Biological Chemistry vol. 267, No. 3, pp. 25676-25684 (1992).
Hsieh, et al: "Mechanistic Aspects of Type-II DNA Topoisomerase" ColdSpring Harbor Laboratory Press (1990), pp. 243-263.
Kim, et al.: "Identification of the Yeast TOP3 Gene Product as a Single Strand-specific DNA Topoisomerase" Journal of Biological Chemistry, vol. 267, No. 24, pp. 17178-17185 (1992).
Hanai, et al.: "Human TOP3: A single-copy gene encoding DNA topoisomerase III" Proc. Natl. Acad. Sci. USA vol. 93, pp. 3653-3657 (1996).
Siedlecki, et al.: "Characterization of a prokaryotic topoisomerase I activity in chloroplast extracts from spinach" Nucleic Acids Research vol. 11, pp. 1523-1536. (1983).
Kikuchi, et al: "DNA Topology and Its Biological Effects" ColdSpring Harbor Laboratory Press (1990), pp. 285-298.
De La Tour, et al.: "Reverse Gyrase in Thermophilic Eubacteria" Journal of Bacteriology vol. 173, No. 12, pp. 3921-3923 (1991).
Slesarev, et al.: "DNA Topoisomerase III from Extremely Thermophilic Archaebacteria" Journal of Biological Chemistry vol.266, No. 19, pp. 12321-12328 (1991).
Neil Osheroff: "Biochemical Basis for the Interactions of Type I and Type II Topoisomerases with DNA" Pharmac. Ther. vol. 41, pp. 223-241 (1989).
Karl Drlica: "Biology of Bacterial Deoxyribonucleic Acid Topoisomerase" Microbiological Reviews vol. 48, No. 4, pp. 273-289 (1984).
Glisson, et al: "DNA Topoisomerase II: A Primer on the Enzyme and its Unique Role as a Multidrug Target in Cancer Chemotherapy" Pharmac. Ther. vol. 32, pp. 89-106 (1987).
Bodley, et al.: "Topoisomerases as Novel Targets for Cancer Chemotherapy" Bio/Technology vol. 6 pp. 1315-1319 (1988).
Leroy F. Liu: "DNA Topoisomerase Poisons as Antitumor Drugs" Annu. Rev. Biochem. vol. 58, pp. 351-375 (1989).
Amy Luttinger: "The Twisted `life` of DNA in the cell: bacterial topoisomerases" Molecular Microbiology vol. 15(4), pp. 601-606 (1995).
Berlani, et al.: "Transfer RNA genes in the cap-oxil region of yeast mitochondrial DNA" Nucleic Acids Research vol. 8, No. 21 (1980).
Joaquim Roca: "The mechanisms of DNA topoisomerases" TIBS vol. 20, pp. 156-160 (1995).
Furata et al. AIDS Research and Human Retroviruses. 10: 1187-1188, 1994.
Gwynn Michael N.
Kallendar Howard
Palmer Leslie M.
Gimmi Edward R.
Jackson Arthur E.
King William T.
Myers Carla J.
SmithKline Beecham Corporation
LandOfFree
Topoisomerase III does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Topoisomerase III, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Topoisomerase III will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1904843