Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Isomerase
Patent
1997-10-14
1999-10-05
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Isomerase
4353201, 4352523, 43525411, 435325, 436 232, 436 2432, C12N 100, C12N 510, C12N 990, C12N 1561, C12N 1563
Patent
active
059623039
ABSTRACT:
Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Streptococcal Topoisomerase III and for detecting the polypeptide in a host.
REFERENCES:
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Gwynn Michael N.
Kallendar Howard
Bugaisky Gabriele E.
Gimmi Edward R.
Jackson Arthur E.
King William T.
SmithKline Beecham Corporation
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