Topoisomerase III

Details Topoisomerase III Topoisomerase III

1999-05-12

2000-12-05

Stole, Einar

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Transferases

424 941, 435183, 435233, 514 2, 514 12, 530300, 530324, 530350, A61K 3851, A61K 3800, C12N 990, C07K 100

Patent

active

061563102

ABSTRACT:
Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase III and for detecting the polypeptide in a host.

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European Search Report completed Nov. 11, 1999 from corresponding European Application No. 97308159.9, filed Oct. 15, 1997.

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