Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-10-14
1999-06-08
Campell, Bruce R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 4353201, 435325, 4352523, 43525411, 536 237, 536 2432, C12Q 168, C07H 2100, C12N 510, C12N 1531
Patent
active
059104147
ABSTRACT:
topoisomerase I polypeptides and DNA and RNA encoding such topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding streptococcal topoisomerase I and for detecting the polypeptide in a host.
REFERENCES:
De Long, GenBank Acc. No. L27797, "Cloning ans sequencing of the Topl gene, the gene encoding B. subtilis DNA Topoisomerase I", US National Library of Medicine, accessed by PTO Oct. 29, 1998, Aug. 1994.
Kim, et al., "Identification of the Yeast TOP3 Gene Product as a Single Strand-specific DNA Topoisomerase." J. Biol. Chem., vol. 267, No. 24: pp. 17178-17185, (1992).
Hanai, et al., "Human TOP3 : A single-copy gene encoding DNA topoisomerase III." Proc. Natl. Acad. Sci., vol. 93: pp. 3653-3657, (1996).
Siedlecki, et al., "Characterization of a prokaryotic topoisomerase I activity in chloroplast extracts from spinach." Nucleic Acids Res., vol. 11, No. 5: pp. 1523-1536, (1983).
Kikuchi, A., In DNA: "Topology and Its Biological Effects" (N.R. Cozzarelli and J.C. Wang, eds.) Cold Spring Harbor Laboratory Press, New York, pp. 285-298, (1990).
Slesarev, et al., "DNA Topoisomerase III from Exremely Thermophilic Archaebacteria" J. Biol. Chem., vol. 266, No. 19: pp. 12321-12328, (1991).
Osheroff, N., "Biochemical Basis for the Inteactions of Type 1 and Type II Topoismerases With DNA." Pharmac. Ther., vol. 41: pp. 223-241, (1989).
Bouthier de la Tour, et al., "Reverse Gyrase in Thermophilic Eubacteria." J. Bact., vol. 173, No. 12: pp. 3921-3923, (1991).
Ben-Yedidia et al., "Design of peptide and polypeptide vaccines", Curr. Opin. Biotechnol. 8: 442-448, Aug. 1997.
Ngo et al., "Computational complexity, protein structure prediction, and the Levinthal paradox", in `The Protein Folding Problem and Tertiary Structure Prediction`, Merz et al. (eds.), Birkhauser Boston: Boston, MA, pp. 433 & 492-495, 1994.
Wang et al., "Cloning of the gene topA encoding for DNA topoisomerase I and the physical mapping of the cysB-topA-trp region of Escherichia coli", Nucleic Acids Res. 11(6): 1773-1790, 1983.
Tse-Dinh et al., "Complete nucleotide sequence of teh topA gene encoding Escherichia coli DNA topoisomerase I", J. Mol. Biol. 191: 321-331, 1986.
Gwynn Michael N.
Kallender Howard
Campell Bruce R.
Gimmi Edward R.
Jackson Arthur E.
King William T.
Priebe Scott D.
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