Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-12-01
1999-09-14
Ceperley, Mary E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 75, 435188, 436537, 436545, 436546, 436815, 5303889, 5303898, 530404, G01N 33533, G01N 33535, C07K 1644, C12N 996
Patent
active
059521872
ABSTRACT:
The present invention provides a topiramate immunoassay and reagents for use in the immunoassay. In particular, topiramate is derivatized at the sulfamate moiety or the 9-carbon or 10-carbon methyl group of topiramate to add a label bound directly or through a linking group for use as a tracer (competitive analyte analog) or to add a linking group bound to a carrier for use as an immunogen to induce anti-topiramate antibodies. Immunoassay methods and kits are also provided.
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Maryanoff et al., "Anticonvulsant .omicron.-Alkyl Sulfamates. 2,3:4,5-Bis-.omicron.-(1-methylethylidene)-.beta.-D-fructopyranose Sulfamate and Related Compounds," J. Med. Cem. 30, (1987), pp. 880-887.
Cawley Daniel B.
Maryanoff Bruce E.
Sorgi Kirk L.
Stenglein Kenneth J.
Ceperley Mary E.
Oxis International Inc.
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