Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2002-01-09
2004-06-29
Wang, Shengjun (Department: 1617)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S078030, C514S675000, C514S763000, C514S845000
Reexamination Certificate
active
06756045
ABSTRACT:
BACKGROUND
The present invention relates to cosmetic and topical dermatological preparations containing an effective amount of idebenone and/or its derivatives. The present invention relates in particular to cosmetic preparations having effective protection from damaging oxidation processes in the skin, but also for the protection of cosmetic preparations themselves, or for the protection of the constituents of cosmetic preparations from damaging oxidation processes. Furthermore, the present invention relates to cosmetic and dermatological preparations containing an effective amount of idebenone and/or its derivatives, which beyond supporting vesicular breathing/cellular respiration or stabilisation of the mitochondrial membranes, promote the regeneration and vitality of skin cells.
The present invention also relates to anti-oxidants, and here preferably those which are used in skin-care cosmetic or dermatological preparations. The invention also relates particularly to cosmetic and dermatological preparations containing such anti-oxidants in combination with idebenone and/or its derivatives. Furthermore, the present invention relates to cosmetic and dermatological preparations for the prophylaxis and treatment of cosmetic and dermnatological skin changes, such as for example skin aging, and here in particular skin aging produced by oxidative or degenerative processes.
Furthermore, the present invention also relates to cosmetic and topical dermatological preparations, in which idebenone and its derivatives are used together with glycosaminoglycans and their salts, in particular hyaluronic acid having a molecular weight of 1 to 1,000,000 and their salts, or hyaluronidase inhibitors, such as for example inter-alpha-trypsin inhibitor. In addition, the present invention also relates to cosmetic and dermatological preparations, in which idebenone and/or its derivatives are esterified using glycosaminoglycans and/or their salts, in particular hyaluronic acid having a molecular weight of 1 to 1,000,000 and their salts or hyaluronidase inhibitors, such as for example inter-alpha-trypsin inhibitor.
Furthermore, the present invention relates to active ingredients and preparations containing those active ingredients for the prophylaxis of erythematous, inflammatory, allergic or autoimmune-reactive symptoms, in particular dermatoses.
The present invention also relates to active ingredient combinations and preparations which serve for the prophylaxis and treatment of light-sensitive skin, in particular photodermatoses.
The damaging effect of the ultraviolet part of solar radiation on the skin is generally known.
While rays having a wavelength which is less than 290 nm, (the so-called UVC range) are absorbed by the ozone layer in the earth's atmosphere, rays in the range between 290 nm and 320 nm, the so-called UVB range, cause an erythema, simple sunburn or even more or less severe burns.
The narrower range around 308 nm is given as a maximum for erythema activity of sunlight. For protection against UVB radiation, numerous compounds are known, in which they are derivatives of 3-benzylidene camphor, 4-aminobenzoic acid, cinnamic acid, salicylic acid, benzophenone and also 2-phenylbenzimidazole.
Also, for the range between about 320 nm and about 400 nm, the so-called UVA range, it is important to have filter substances available, since its rays may cause reactions in light-sensitive skin. It has been proved that UVA radiation leads to damage of the elastic and collagenic fibres of the connective tissue, which allows the skin to age prematurely, and that it is to be regarded as a cause of numerous phototoxic and photoallergic reactions. The damaging influence of UVB radiation may be amplified by UVA radiation. It has also been proved that consumption of lipophilic anti-oxidants, for example alpha-tocopherol, is triggered in the skin by UVA and UVB radiation (Thiele et al., J. Invest. Dermatol. 110, page 756 ff. (1998)).
For protection against the rays of the UVA range, certain derivatives of dibenzoylmethane have therefore been used, the photostability of which (Int. J. Cosm. Science 10, 53 (1988)) is not provided to an adequate extent. However, UV radiation may also lead to photochemical reactions, wherein then the photochemical reaction products intervene in the skin mechanism.
Predominantly such photochemical reaction products are free-radical compounds, for example hydroxy radicals. Also, undefined free-radial photoproducts, which are produced in the skin itself, may trigger uncontrolled side reactions due to their high reactivity. However, singlet oxygen, a non-free-radical excited state of the oxygen molecule, may occur on UV irradiation, likewise short-lived epoxides and many others. Singlet oxygen, for example is characterised with respect to the normally existing triplet oxygen (free-radical base state) by increased reactivity. Nevertheless, excited, reactive (free-radical) triplet states of the oxygen molecule also exist. Furthermore, there is the occurrence of lipid peroxidation products, such as for example hydroperoxides and aldehydes, wherein first in turn free-radical chain reactions may be triggered and to which overall cytotoxic properties have to be ascribed (Michiels and Remacle, Toxicology, 66, 225 ff. (1990)).
Furthermore, UV radiation is ionising radiation. Hence, there is the risk that also ionic species are produced on UV exposure, which then in turn are able to intervene oxidatively in the biochemical processes.
In order to prevent these reactions, additional anti-oxidants and/or free-radical absorbers/scavengers may be incorporated in the cosmetic or dermatological formulations.
It has already been proposed to use vitamin E, a substance having known anti-oxidative action in sunscreen formulations, nevertheless even here the action achieved remains far below that hoped for. The production of pro-oxidative degradation products of tocopherol should be mentioned.
Patent Documents DE 3 049 039, European 0 788 793 (13.8.1997), U.S. Pat. No. 4,436,753, U.S. Pat. No. 5,059,627, U.S. Pat. No. 5,916,925 and World 99 07 355 (see examples) indeed describe oral, parenteral or percutaneous preparations containing idebenone or its derivatives for the treatment of dementia, circulatory disturbances or for the induction of a neural growth factor. Patent document JP 1 279 818 describes the use of idebenone and its derivatives in various preparations for colouring hair. Idebenone showed no toxic effects on oral administration (Barkworth et al., Arzneim.-Forsch/Drug Res. 35 (II), 11, pages 1704 ff. (1985)).
Other investigations have also shown that idebenone and/or its derivatives shows protection against the loss of alpha-tocopherol and coenzyme Q-10 in the tissue under pro-oxidative conditions (Schütz et al., Clin. Biochem. 30, 619 ff. (1997)).
Light-sensitive skin includes photodermatoses. Further designations for the polymorphic light-dermatosis are PLD, PLE, Mallorca Acne and a plurality of further designations, as are given in the literature (for example A. Voelckel et al., Zentralblatt Hautund Geschlechtskrankheiten (1989), 156, page2).
Erythematous skin symptoms also occur as concomitant symptoms in ceratin skin diseases or skin irregularities. For example, the typical rash in the clinical picture of acne is regularly reddened to a greater or lesser extent.
Anti-oxidants are mainly used a protectie substances against the decay of the preparations containing them. Nevertheless, it is known that undesirable oxidation processes may also occur in the human and animal skin. Such processes play a considerabe part in skin aging.
Oxidative damage to the skin and its more detailed causes are listed in the essay “Skin Diseases Associated with Oxidative Injury” in “Oxidative Stress in Dermatology”, page 323 ff. (Marcel Decker Inc., New York, Basle, Hong Kong, Publisher: Jürgen Fuchs, Frankfurt, and Lester Packer, Berkeley/Calif.).
Anti-oxidants are substances which prevent oxidation processes or which prevent the autooxidation of fats containing unsaturated compounds. Anti-oxidants w
Diedrich Falko
Neudecker Birgit
Wieland Eberhard
Davidson Davidson & Kappel LLC
Wang Shengjun
LandOfFree
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