Topically administrable compositions containing 3-benzoylphenyla

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514535, 514570, 514617, 514618, 514621, A61K 31165

Patent

active

054750342

ABSTRACT:
Novel ester and amide derivatives of 3-benzoylphenylacetic acid are disclosed. The use of these novel derivatives and certain known derivatives in topically administrable compositions for the treatment of ophthalmic inflammatory disorders is also disclosed.

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Sancillo et al., "AHR-10037, a non-steroidal anti-inflammatory compound of low gastric toxicity," Agents and Actions, 31:117-126 (1990).
Walsh et al., "Antiinflammatory Agents. 3. Synthesis and Pharmacological Evaluation of 2-Amino-3-benzoylphenylacetic Acid and Analogues," J. Med. Chem. 27:1379-1388 (1984).
Walsh et al., "Antiinflammatory Agents. 4. Synthesis and Biological Evaluation of Potential Prodrugs of 2-Amino-3-benzoylbenzeneacetic Acid and 2-Amino-3-(4-chlorobenzoyl)benzeneacetic Acid," J. Med. Chem. 33:2296-2304 (1990).

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