Topical use of antibodies for prevention or treatment of pseudom

Details Topical use of antibodies for prevention or treatment of pseudom Topical use of antibodies for prevention or treatment of pseudom

1989-03-17

1991-02-19

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

4352533, A61K 3900, A61K 39104

Patent

active

049942697

ABSTRACT:
Method of preventing or treating a Pseudomonas aeruginosa infection. Method comprises topical application of antibodies to P. aeruginos under conditions and in an amount sufficient to prevent or treat the infection in a mammal. In one embodiment, the antibodies are administrered in form of an aerosol. A preferred dosage for polyclonal antibody preparations (i.e. ISG or high titer P. aeruginosa ISG) ranges from 2 mg/kg to 100 mg/kg body weight of the mammal. A preferred monoclonal antibody dosage ranges from 0.02 to 1.0 mg/kg of body weight.

REFERENCES:
patent: 4800078 (1989-01-01), Prince et al.
Bessen, J. Exp. Med., vol. 167, pp. 1945-1950, Jun. 1988.
Akerfeldt et al., Biochemical Pharmacology, vol. 22, pp. 2911-2917, 1973.

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