Topical treatment of ocular pain after corneal surgery

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514912, A61K 31195

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active

061179078

ABSTRACT:
Post-operative method for the treatment of ocular pain following corneal reprofiling surgery by topical administration of an ophthalmic nonsteroidal solution and an ophthalmic steroidal composition. The nonsteroidal solution comprises a non-steroidal anti-inflammatory agent such as diclofenac sodium and the steroidal composition contains a corticosteroid such as fluorometholone. These ophthalmic medicaments when used in combination reduce the post-operative pain particularly associated with phototherapeutic keratectomy and photorefractive keratectomy performed with an excimer laser and promote re-epithelialization over the reprofiled corneal surface.

REFERENCES:
patent: 4619926 (1986-10-01), Eckert
patent: 4665913 (1987-05-01), L'Esperance, Jr.
patent: 4829088 (1989-05-01), Doulakas
patent: 4960799 (1990-10-01), Nagy
patent: 5149693 (1992-09-01), Cagle et al.
Ocular Therapeutics and Pharmacology, Sixth Edition, 1981, pp. 28,258 and 259.
Frucht-Pery, J., et al., "The Effect of Topical Administration of Indomethacin on Symptoms in Corneal Scars and Edema", American Journal of Opthamology, 112, 186-190, (Aug. 1991).
"The Effect Of Topical Non Steroidal Anti Inflammatory Drugs (NSAIDS) In Excimer Laser Photorefractive Keratectomy (PRK)" by Steve A. Arshinoff, M.D., ASCRS Symposium, Apr. 15, 1992, San Diego, CA.
N.A. Sher Et Al., Archives Of Ophthalmology, vol. 110, Jul. 1992, pp. 935-943.
"Excimer Lasers In Ophthalmology" by Neal A. Sher, Annual Clao Meeting, Jan. 1992, Las Vegas, NV. Note Attached "Exhibit A".
Agata Et Al., Folia Ophth. Japonica, vol. 35, 1984, pp. 604-612.
A. J. Flach, "Cyclo-oxygenase Inhibitors in Ophthalmology," Survey of Ophthalmology, 36, 259-284 (1992).
H. van Husen, Klin. Monatbl. Augenheilk. 188, pp. 615-619 (1986). [English Abstract Provided].
Ophthalmology Times, Oct. 15, 1991, p. 14.
Ophthalmology Times, Mar. 15, 1993, pp. 26-28.
Araie et al., Jpn. J. Ophthalmol. 27, pp. 535-542 (1983).
Ocular Surgery News, Mar. 15, 1993, p. 64.
Ocular Surgery News, May 1, 1992, pp. 24-25.
Monatsbl. Augenheilk. 200, 362-366 (1992). [English Abstract Only).
Physicians Desk Reference For Ophthalmology, 20 Edition, pp. 268-269 (1992).
"Flurbiprofen-An Ophthalmic NSAID", The Medical Letter on Drugs and Therapeutics, 29, 59 (1987).
Skoutakis et al., "Review of Diclofenac and Evaluation of its Place in Therapy as a Nonsteroidal Antiinflammatory Agent", Drug Intell.& Clin. Pharm., 22, 850 (1988).
Podos et al., "Comparison of ocular prostaglandin synthesis inhibitors", Investig. Opthal., 15, 841 (1976).
Rooks et al., "The Analgesic and Anti-Inflammatory Profile of Ketorolac and its Tromethamine Salts", Drugs Exptl. Clin. Res., XI(8), 479 (1985).
Todd et al., "Suprofen: A Review of its Pharmacodynamic and Phamracokinetic Properties, and Analgesic Efficacy", Drugs, 30, 514 (1985).
Kantor, "Use of Diclofenac in Analgesia", Amer. J. Med., 80, 64 (1986).

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