Topical treatment of blepharitis

Details Topical treatment of blepharitis Topical treatment of blepharitis

1988-06-09

1990-09-18

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514398, 514914, A61K 31415, A61K 31535

Patent

active

049579185

ABSTRACT:
A method and composition for treating blepharitis or blepharoconjunctivitis comprises topical administration of a nitroimidazole compound, e.g. metronidazole in a suitable carrier directly to affected ocular tissues. The carrier can be an artificial tear solution or an ointment or water soluble gel base.

REFERENCES:
patent: 4041168 (1977-08-01), Assandri et al.
patent: 4491588 (1985-01-01), Rosenburg et al.
Chemical Abstracts, 98:209546a (Mattila et al.), 1983.
"Ocular Rosacea" by M. S. Jenkins et al., American Journal Ophthalmology, vol. 88:618-622 (1979).
"Blepharitis Associated with Acne Rosacea and Seborrheic Dermatitis" by J. P. McCulley et al., Oculocutaneous Diseases, edited by J. P. Callen et al., Little, Brown, & Company, International Ophthalmology Clinics, Spring 1985, vol. 25, No. 1, pp. 159-172.
"Ocular Rosacea" by D. J. Browning et al., Survey of Ophthalmology, vol. 31, No. 3, Nov.-Dec. 1986, pp. 145-158.
Textbook of Dermatology, 4th Edition, A. Rook et al., editors, vol. 2, p. 2152.
"Topical Metronidazole Therapy for Rosacea" by P. A. Bleicher et al., Arch. Dermatol., vol. 123, May 1987, pp. 609-614.
Diseases of the Cornea, 2nd Edition, by M. G. Grayson, C. Z. Mosby Company, 1983, pp. 199-209.
"Tear Physiology and Dry Eyes" by F. J. Holly et al., Survey of Ophthalmology, vol. 22, No. 2, Sep.-Oct. 1977, pp. 69-87.

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